Autistic traits in children with ADHD index clinical and cognitive problems.
Autistic traits in children with ADHD index clinical and cognitive problems.
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DOI：
10.1007/s00787-013-0398-6
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发表时间：
2014-01
影响因子：
6.4
通讯作者：
Thapar, Anita
中科院分区：
文献类型：
--
作者：
Cooper, Miriam;Martin, Joanna;Langley, Kate;Hamshere, Marian;Thapar, Anita
自闭症谱系障碍（ASD）的特征经常出现在注意缺陷多动障碍（ADHD）中，但其存在的表型和潜在的神经生物学方面的意义并没有得到正确的理解。这项分析的目的是确定是否更高水平的自闭症特征，社会沟通问卷（SCQ），指数更严重的介绍在一个大的，严格的表型样本的ADHD儿童（N = 711）。回归分析用于检查SCQ评分与核心ADHD特征、临床合并症以及认知和发育特征的相关性，并对假定的混杂因素进行调整。对于显示与SCQ总分相关的结局，次要分析确定了三个ASD子域的差异相关性水平。结果表明，ADHD中ASD的增加与对立，行为和焦虑症状，较低的全面智商，工作记忆缺陷和一般运动问题方面的更严重的表型相关。这些协会持续占ADHD的严重程度后，表明自闭症障碍独立指数的严重程度共病障碍的背景下，ADHD。子域分数并没有显示出独特的贡献，大多数结果，除了社会赤字独立与对立症状和重复行为独立预测多动冲动症状和运动问题。对于临床医生来说，考虑那些不符合ASD诊断标准的ADHD患者的社会沟通和重复特征水平是值得的，因为它们指示更高水平的表型复杂性，这可能对干预措施的有效性产生影响。本文的在线版本（doi：10.1007/s 00787 -013-0398-6）包含补充材料，可供授权用户使用。
Traits of autistic spectrum disorders (ASD) occur frequently in attention deficit hyperactivity disorder (ADHD), but the significance of their presence in terms of phenotype and underlying neurobiology is not properly understood. This analysis aimed to determine whether higher levels of autistic traits, as measured by the Social Communication Questionnaire (SCQ), index a more severe presentation in a large, rigorously phenotyped sample of children with ADHD (N = 711). Regression analyses were used to examine association of SCQ scores with core ADHD features, clinical comorbidities and cognitive and developmental features, with adjustment for putative confounders. For outcomes showing association with total SCQ score, secondary analyses determined levels of differential association of the three ASD sub-domains. Results suggest that increasing ASD symptomatology within ADHD is associated with a more severe phenotype in terms of oppositional, conduct and anxiety symptoms, lower full-scale IQ, working memory deficits and general motor problems. These associations persisted after accounting for ADHD severity, suggesting that autistic symptomatology independently indexes the severity of comorbid impairments in the context of ADHD. Sub-domain scores did not show unique contributions to most outcomes, except that social deficits were independently associated with oppositional symptoms and repetitive behaviours independently predicted hyperactive-impulsive symptoms and motor problems. It would be worthwhile for clinicians to consider levels of socio-communicative and repetitive traits in those with ADHD who do not meet diagnostic criteria for ASD, as they index higher levels of phenotypic complexity, which may have implications for efficacy of interventions. The online version of this article (doi:10.1007/s00787-013-0398-6) contains supplementary material, which is available to authorized users.
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影响因子：
3
作者：
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通讯作者：
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DOI：
10.1007/s10882-010-9199-8
发表时间：
2010-08-01
影响因子：
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作者：
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通讯作者：
Castellanos, F. Xavier
DOI：
10.1111/j.1469-7610.2010.02215.x
发表时间：
2010-07-01
影响因子：
7.6
作者：
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通讯作者：
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