Lamina Cribrosa and Choroid Features and Their Relationship to Stage of Pseudoexfoliation Glaucoma.
Lamina Cribrosa and Choroid Features and Their Relationship to Stage of Pseudoexfoliation Glaucoma.
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DOI：
10.1167/iovs.18-25035
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发表时间：
2018-11-01
影响因子：
4.4
通讯作者：
Weinreb RN
中科院分区：
文献类型：
--
作者：
Moghimi S;Nekoozadeh S;Motamed-Gorji N;Chen R;Fard MA;Mohammadi M;Weinreb RN
为了更好地了解筛板（LC）和脉络膜特征与假性脱落性青光眼（PXG）严重程度的关系。在本横断研究中，122名受试者137只眼（47只眼为中度/晚期PXG[平均偏差（MD），−15.0±7.7 dB]， 34只眼为轻度PXG [MD，−2.7±1.5 dB]， 32只眼为年龄匹配的假性脱落综合征[PXS]， 24只眼为年龄匹配的对照）进行了调查。测量视盘、LC厚度、前LC深度（ALD；上中、中、下中）以及乳头周围脉络膜厚度。线性混合模型用于调整年龄、性别和轴长。与对照组（271.9±61.3 μm）、PXS组（212.6±51.5 μm）、轻度PXG组（180.8±24.6 μm）和中度/高级PXG组（138.9±37.5 μm）相比，LC厚度逐渐减小（P < 0.001）。ALD在中晚期青光眼（306.7±105.3 μm）和轻度PXG（209.5±79.7 μm）组高于PXS（155±86.7 μm）和健康对照组（149.2±103 μm）组（P < 0.001）。中度/晚期PXG患者的脉膜厚度最薄（117.2±36.6 μm），但轻度PXG、PXS和对照组的脉膜厚度相当（分别为150.0±46.1、159.7±65.5和157.5±51.1 μm, P = 0.002）。MD恶化是PXG眼LC变薄（β = 2.344, P < 0.001）和脉络膜变薄（β = 1.717, P = 0.009 μm）的唯一相关因素。较高的IOP （β = 4.305, P = 0.013）和较差的MD （β = - 6.390, P < 0.001）与PXG中更深的ALD相关。在假脱落中，LC变薄是一个早期征兆，并且随着青光眼的进展而逐渐变薄。脉络膜变薄仅在中度/晚期青光眼中可见。在PXG眼中，LC厚度、深度和乳头周围脉络膜厚度与青光眼的严重程度相关。
To better understand the relationship of lamina cribrosa (LC) and choroid features to the severity of pseudoexfoliation glaucoma (PXG). In this cross-sectional study, 137 eyes of 122 subjects (47 eyes with moderate/advanced PXG [mean deviation (MD), −15.0 ± 7.7 dB], 34 eyes with mild PXG [MD, −2.7 ± 1.5 dB], 32 aged-matched pseudoexfoliation syndrome [PXS] eyes, and 24 aged-matched control eyes) were investigated. Optic discs, LC thickness, and anterior LC depth (ALD; midsuperior, center, and midinferior) as well as peripapillary choroidal thickness were determined. Linear mixed modeling was used to adjust for age, sex, and axial length. A progressive decrease in LC thickness was found when comparing controls (271.9 ± 61.3 μm), PXS (212.6 ± 51.5 μm), mild PXG (180.8 ± 24.6 μm), and moderate/advance PXG (138.9 ± 37.5 μm) (P < 0.001). ALD was greater (P < 0.001) in moderate/advance glaucoma (306.7 ± 105.3 μm) and mild PXG (209.5 ± 79.7 μm) compared with PXS (155 ± 86.7 μm) and healthy controls (149.2 ± 103 μm). Although eyes with moderate/advance PXG had the thinnest choroid (117.2 ± 36.6 μm), choroidal thickness was comparable in mild PXG, PXS, and controls (150.0 ± 46.1, 159.7 ± 65.5, and 157.5 ± 51.1 μm, respectively; P = 0.002). Worse MD was the only factor associated with thinner LC (β = 2.344, P < 0.001) and choroid (β = 1.717, P = 0.009 μm) in PXG eyes. Higher IOP (β = 4.305, P = 0.013) and worse MD (β = −6.390, P < 0.001) were associated with deeper ALD in PXG. In pseudoexfoliation, LC thinning is an early sign, and there is progressive thinning with advancing glaucoma. Choroidal thinning is observable only with moderate/advanced glaucoma. In PXG eyes, LC thickness, depth, and peripapillary choroidal thickness are associated with glaucoma severity.
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影响因子：
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