Neural Correlates for Intrinsic Motivational Deficits of Schizophrenia; Implications for Therapeutics of Cognitive Impairment.
Neural Correlates for Intrinsic Motivational Deficits of Schizophrenia; Implications for Therapeutics of Cognitive Impairment.
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DOI：
10.3389/fpsyt.2018.00178
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发表时间：
2018
影响因子：
4.7
通讯作者：
Nakagome K
中科院分区：
文献类型：
--
作者：
Takeda K;Sumiyoshi T;Matsumoto M;Murayama K;Ikezawa S;Matsumoto K;Nakagome K
精神分裂症治疗的最终目标是康复，这是一个与改善认知和社会功能有关的概念。认知补救疗法(CRT)是最有效的认知增强方法之一，已被证明可以适度改善社会功能。为此，与兴趣和享受等内在价值相关的内在动机已被证明发挥了关键作用。虽然内在动机受损是精神分裂症的特征之一，但其神经机制尚不清楚。这与缺乏可行的内在动机措施及其对治疗的反应有关。根据自我决定理论(SDT)，不仅内在动机而且外在动机在一定程度上促进了健康受试者的学习和记忆。这一发现表明，不同类型的动机对增强CRT治疗精神分裂症认知障碍的能力有贡献。本文就健康受试者和精神分裂症患者内在动机的心理特征、测评方法和神经相关因素进行综述。特别是，我们专注于内在动机的神经成像研究，包括我们自己的动机。这些考虑与提高精神分裂症的功能结局有关。
The ultimate goal of the treatment of schizophrenia is recovery, a notion related to improvement of cognitive and social functioning. Cognitive remediation therapies (CRT), one of the most effective cognition enhancing methods, have been shown to moderately improve social functioning. For this purpose, intrinsic motivation, related to internal values such as interest and enjoyment, has been shown to play a key role. Although the impairment of intrinsic motivation is one of the characteristics of schizophrenia, its neural mechanisms remain unclear. This is related to the lack of feasible measures of intrinsic motivation, and its response to treatment. According to the self-determination theory (SDT), not only intrinsic motivation, but extrinsic motivation has been reported to enhance learning and memory in healthy subjects to some extent. This finding suggests the contribution of different types of motivation to potentiate the ability of the CRT to treat cognitive impairment of schizophrenia. In this paper, we provide a review of psychological characteristics, assessment methods, and neural correlates of intrinsic motivation in healthy subjects and patients with schizophrenia. Particularly, we focus on neuroimaging studies of intrinsic motivation, including our own. These considerations are relevant to enhancement of functional outcomes of schizophrenia.
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影响因子：
3
作者：
Basar-Eroglu, Canan;Brand, Andreas;Schmiedt, Christina
通讯作者：
Schmiedt, Christina
DOI：
10.1073/pnas.0609440103
发表时间：
2006-12-26
影响因子：
11.1
作者：
Cho, R. Y.;Konecky, R. O.;Carter, C. S.
通讯作者：
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影响因子：
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作者：
DECI, EL
通讯作者：
DECI, EL
影响因子：
5.7
作者：
Farrer, C;Franck, N;Jeannerod, A
通讯作者：
Jeannerod, A
影响因子：
4.5
作者：
Barr, M. S.;Farzan, F.;Daskalakis, Z. J.
通讯作者：
Daskalakis, Z. J.