Cerebellar Contribution to Social Cognition.
Cerebellar Contribution to Social Cognition.
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DOI：
10.1007/s12311-015-0746-9
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发表时间：
2016-12
期刊：
影响因子：
3.5
通讯作者：
Schmahmann, Jeremy D.
中科院分区：
文献类型：
--
作者：
Hoche, Franziska;Guell, Xavier;Sherman, Janet C.;Vangel, Mark G.;Schmahmann, Jeremy D.
关键词：
面部情绪归因（EA）是社会认知的关键，而面部情绪感知缺陷是小脑病理报道的神经精神疾病的基础。在这里，我们验证了小脑通过面孔的EA参与社会认知的假设。我们检查了57名小脑疾病患者和57名健康对照者。复杂脑小脑疾病31例；26例分离到小脑。EA通过“通过眼睛读心术”任务（RMET）来测量，并对被调查者进行了一项新的问卷调查，即小脑神经精神病学评定量表（CNRS）。所有患者的EA均受损（CD p< 0.001, ID p< 0.001）。当对效价分类进行分析时，CD和ID都错过了更多的积极和消极刺激。阳性目标产生最高的赤字（CD p<0.001, ID p=0.004）。EA损伤与CNRS测量的社交技能缺陷（p< 0.05）和自闭症谱系行为（p< 0.005）相关。患者存在情绪调节困难（CD p< 0.001, ID p< 0.001）、自闭症谱系行为困难（CD p< 0.049, ID p< 0.001）、精神病谱系症状困难（CD p< 0.021, ID p< 0.002）。ID被调查者认为缺乏社交技能（CD p<.746, ID p<.003）和注意力调节障碍（CD p<.144, ID p<.001）。在精神病谱域内，CD患者在共情缺乏方面比对照组更差（CD p=0.05; ID p=0.49）。因此，患有小脑损伤的患者在EA任务中受损，与缺乏社交技能和自闭症谱系行为有关，并且在CNRS中经历了心理社会困难。这与共济失调、小脑认知情感/ Schmahmann综合征和伴有小脑病理的神经精神疾病有关。
Emotion attribution (EA) from faces is key to social cognition, and deficits in perception of emotions from faces underlie neuropsychiatric disorders in which cerebellar pathology is reported. Here we test the hypothesis that the cerebellum contributes to social cognition through EA from faces. We examined fifty-seven patients with cerebellar disorders and 57 healthy controls. Thirty-one patients had complex cerebrocerebellar disease (CD); 26 had disease isolated to cerebellum (ID). EA was measured with the Reading the Mind in the Eyes task (RMET), and informants were administered a novel questionnaire, the Cerebellar Neuropsychiatric Rating Scale (CNRS). EA was impaired in all patients (CD p<.001, ID p<.001). When analyzed for valence categories, both CD and ID missed more positive and negative stimuli. Positive targets produced the highest deficit (CD p<0.001, ID p=0.004). EA impairments correlated with CNRS measures of deficient social skills (p<.05) and autism spectrum behaviors (p<.005). Patients had difficulties with emotion regulation (CD p<.001, ID p<.001), autism spectrum behaviors (CD p<.049, ID p<.001), and psychosis spectrum symptoms (CD p<.021, ID p<.002). ID informants endorsed deficient social skills (CD p<.746, ID p<.003) and impaired attention regulation (CD p<.144, ID p<.001). Within the psychosis spectrum domain, CD patients were worse than controls for lack of empathy (CD p=0.05; ID p=0.49). Thus, patients with cerebellar damage were impaired on an EA task associated with deficient social skills and autism spectrum behaviors, and experienced psychosocial difficulties on the CNRS. This has relevance for ataxias, the cerebellar cognitive affective / Schmahmann syndrome, and neuropsychiatric disorders with cerebellar pathology.
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影响因子：
2.9
作者：
Byom LJ;Mutlu B
通讯作者：
Mutlu B
影响因子：
5.7
作者：
Baumann, Oliver;Mattingley, Jason B.
通讯作者：
Mattingley, Jason B.
影响因子：
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作者：
Adamaszek, M.;D'Agata, F.;Strecker, K.
通讯作者：
Strecker, K.
DOI：
10.1098/rstb.2010.0362
发表时间：
2011-06-12
期刊：
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
影响因子：
--
作者：
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通讯作者：
Passamonti L
影响因子：
3.6
作者：
Brüne, M
通讯作者：
Brüne, M