Role of astrocytes in sleep deprivation: accomplices, resisters, or bystanders?
Role of astrocytes in sleep deprivation: accomplices, resisters, or bystanders?
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星形胶质细胞在睡眠剥夺中的作用：共犯、抵抗者还是旁观者？
DOI：
10.3389/fncel.2023.1188306
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发表时间：
2023
影响因子：
5.3
通讯作者：
Zhou, Zhiqiang
中科院分区：
文献类型：
--
作者：
Que, Mengxin;Li, Yujuan;Wang, Xuan;Zhan, Gaofeng;Luo, Xiaoxiao;Zhou, Zhiqiang
睡眠在所有被研究的动物的神经系统中都起着至关重要的作用。然而，睡眠剥夺会导致各种病理变化和神经行为问题。星形胶质细胞是大脑中最丰富的细胞，参与多种重要功能，包括神经递质和离子稳态、突触和神经元调节、血脑屏障维持；此外，它们还与许多神经退行性疾病、疼痛和情绪障碍有关。此外，星形胶质细胞越来越被认为是调节睡眠-觉醒周期的重要贡献者，无论是局部的还是特定的神经回路。在这篇综述中，我们首先描述星形胶质细胞在调节睡眠和昼夜节律中的作用，重点是：(i)神经元活动；(2)代谢;（iii）淋巴系统；(四)神经炎症;星形胶质细胞-小胶质细胞串扰。此外，我们回顾了星形胶质细胞在睡眠剥夺合并症和睡眠剥夺相关脑部疾病中的作用。最后，我们讨论了针对星形胶质细胞的潜在干预措施，以预防或治疗与睡眠剥夺相关的脑部疾病。探究这些问题将为更深入地理解睡眠剥夺伴随的大脑疾病背后的细胞和神经机制铺平道路。
Sleep plays an essential role in all studied animals with a nervous system. However, sleep deprivation leads to various pathological changes and neurobehavioral problems. Astrocytes are the most abundant cells in the brain and are involved in various important functions, including neurotransmitter and ion homeostasis, synaptic and neuronal modulation, and blood–brain barrier maintenance; furthermore, they are associated with numerous neurodegenerative diseases, pain, and mood disorders. Moreover, astrocytes are increasingly being recognized as vital contributors to the regulation of sleep-wake cycles, both locally and in specific neural circuits. In this review, we begin by describing the role of astrocytes in regulating sleep and circadian rhythms, focusing on: (i) neuronal activity; (ii) metabolism; (iii) the glymphatic system; (iv) neuroinflammation; and (v) astrocyte–microglia cross-talk. Moreover, we review the role of astrocytes in sleep deprivation comorbidities and sleep deprivation-related brain disorders. Finally, we discuss potential interventions targeting astrocytes to prevent or treat sleep deprivation-related brain disorders. Pursuing these questions would pave the way for a deeper understanding of the cellular and neural mechanisms underlying sleep deprivation-comorbid brain disorders.
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影响因子：
4.7
作者：
Araque A;Castillo PE;Manzoni OJ;Tonini R
通讯作者：
Tonini R
影响因子：
82.9
作者：
Alexandre C;Latremoliere A;Ferreira A;Miracca G;Yamamoto M;Scammell TE;Woolf CJ
通讯作者：
Woolf CJ
DOI：
10.1177/1352458514530021
发表时间：
2014-10
期刊：
Multiple sclerosis (Houndmills, Basingstoke, England)
影响因子：
--
作者：
Westerlind H;Boström I;Stawiarz L;Landtblom AM;Almqvist C;Hillert J
通讯作者：
Hillert J
影响因子：
4.2
作者：
Aronica E;Sandau US;Iyer A;Boison D
通讯作者：
Boison D
影响因子：
64.8
作者：
Bezzi, P;Carmignoto, G;Volterra, A
通讯作者：
Volterra, A