Women with PTSD have lower basal salivary cortisol levels later in the day than do men with PTSD: a preliminary study.
Women with PTSD have lower basal salivary cortisol levels later in the day than do men with PTSD: a preliminary study.
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DOI：
10.1016/j.physbeh.2009.06.002
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发表时间：
2010-02-09
影响因子：
2.9
通讯作者：
Frye, Cheryl
中科院分区：
文献类型：
--
作者：
Freidenberg, Brian M.;Gusmano, Rebecca;Hickling, Edward J.;Blanchard, Edward B.;Bremner, J. Douglas;Frye, Cheryl
女性的急性应激反应通常比男性更具反应性。与男性相比，女性可能更容易患创伤后应激障碍（PTSD）。一项试点研究调查了患有创伤后应激障碍的女性和男性的应激激素皮质醇水平是否存在差异。患有 PTSD 的女性 (n=6) 和男性 (n=3) 机动车事故 (MVA) 幸存者在 1400 小时、1800 小时和 2200 小时收集了唾液。通过放射免疫测定法测量唾液中的皮质醇水平。由于女性的皮质醇水平较低并且随着时间的推移而下降，而男性的皮质醇水平较高并且随着收集时间的推移而增加，因此观察到性别和样本采集时间之间的相互作用。这项初步研究的结果表明，患有 PTSD 的女性和男性糖皮质激素分泌中断的模式存在差异。女性的基础皮质醇水平比男性受到更大的抑制；然而，在女性中观察到皮质醇水平全天下降的昼夜模式，但在男性中却没有观察到。
Acute stress responses of women are typically more reactive than that of men. Women, compared to men, may be more vulnerable to posttraumatic stress disorder (PTSD). Whether there are differences between women and men with PTSD in levels of the stress hormone, cortisol, was investigated in a pilot study. women (n=6) and men (n=3) motor vehicle accident (MVA) survivors, with PTSD, had saliva collected at 1400 h, 1800 h, and 2200 h. Cortisol levels in saliva were measured by radioimmunoassay. An interaction between gender and time of sample collection was observed due to women’s cortisol levels being lower and decreasing over time, whereas men’s levels were higher and increased across time of day of collection. Results of this pilot study suggest a difference in the pattern of disruption of glucocorticoid secretion among women and men with PTSD. Women had greater suppression of their basal cortisol levels than did men; however, the diurnal pattern for cortisol levels to decline throughout the day was observed among the women but not the men.
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影响因子：
--
作者：
KESSLER, RC;SONNEGA, A;NELSON, CB
通讯作者：
NELSON, CB
DOI：
10.1111/j.1749-6632.1997.tb48299.x
发表时间：
1997-01-01
期刊：
PSYCHOBIOLOGY OF POSTTRAUMATIC STRESS DISORDER
影响因子：
--
作者：
McFarlane, AC;Atchison, M;Yehuda, R
通讯作者：
Yehuda, R
影响因子：
5.9
作者：
NORRIS, FH
通讯作者：
NORRIS, FH
影响因子：
4.2
作者：
HEUSER, IJ;GOTTHARDT, U;HOLSBOER, F
通讯作者：
HOLSBOER, F
影响因子：
1.9
作者：
MASON, JW;GILLER, EL;PODD, L
通讯作者：
PODD, L