Androgens in various fluid compartments of the rat testis and epididymis after hypophysectomy and gonadotropin supplementation.
Androgens in various fluid compartments of the rat testis and epididymis after hypophysectomy and gonadotropin supplementation.
复制标题
垂体切除术和补充促性腺激素后大鼠睾丸和附睾各个液体室中的雄激素。
作者：
Terry T. Turner;Larry L. Ewing;C. E. Jones;Stuart S. Howards;B. Zegeye
垂体切除的雄性大鼠给予LH或LH + FSH 14天，并进行生殖道液体的体内微穿刺收集，以确定FSH是否改变大鼠睾丸中睾酮或附睾中5 α-二氢睾酮（DHT）的区室化。在心脏血清、睾丸静脉血清、睾丸间质液和曲细精管液以及附睾头和尾部的管腔内液和组织提取物中测定了睾酮和DHT浓度。睾酮是睾丸中的主要雄激素，与对照值相比，通过补充24微克LH/天，静脉血清、间质液和小管液中的浓度恢复至与对照无区别的值。24 μ g LH + 24 μ g FSH/天不能增加睾丸酮的小管内分配。单独使用LH时，附睾DHT值恢复到对照水平，但额外补充FSH可显著增加附睾头的DHT。据推测，FSH不会改变雄激素在大鼠睾丸中的区室化，但可能在保留雄激素在附睾中发挥作用。
Hypophysectomized male rats were administered LH or LH + FSH for 14 days and subjected to in vivo micropuncture collection of reproductive tract fluids to determine if FSH alters the compartmentalization of testosterone in the rat testis or of 5 alpha-dihydrotestosterone (DHT) in the epididymis. Testosterone and DHT concentrations were determined in cardiac blood serum, testicular venous serum, testicular interstitial fluid, and seminiferous tubule fluid, and in intraluminal fluid and tissue extracts from the caput and cauda epididymidis. Testosterone is the predominant androgen in the testis, and compared with control values, concentrations in venous sera, interstitial fluid, and tubule fluid were returned to values indistinguishable from controls by supplementation with 24 micrograms LH/day. 24 micrograms LH + 24 micrograms FSH/day did not augment the intratubular partition of testosterone. Epididymal DHT values were returned to control levels by LH alone, but additional supplementation with FSH significantly increased DHT from the caput epididymidis even further. It is speculated that FSH does not alter the compartmentalization of androgens in the rat testis, but may play a role in retaining androgens in the epididymis.
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DOI：
--
发表时间：
1981-11
期刊：
Investigative urology
影响因子：
--
作者：
R. Cochran;L. Ewing;G. Niswender
通讯作者：
R. Cochran;L. Ewing;G. Niswender
影响因子：
4.8
作者：
Catherine Tananis Anthony;B. J. Danzo;M. Orgebin‐Crist
通讯作者：
Catherine Tananis Anthony;B. J. Danzo;M. Orgebin‐Crist
雄性大鼠生殖道液体中的雄激素：垂体切除术和类固醇替代。
DOI：
10.1152/ajpendo.1985.248.3.e274
发表时间：
1985
期刊：
The American journal of physiology
影响因子：
--
作者：
Turner,TT;Ewing,LL;Jones,CE;Howards,SS;Zegeye,B
通讯作者：
Zegeye,B
通过施用卵泡刺激素，促性腺激素抑制的正常男性重新启动精子产生。
DOI：
10.1172/jci111024
发表时间：
1983
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Matsumoto,AM;Karpas,AE;Paulsen,CA;Bremner,WJ
通讯作者：
Bremner,WJ
比格犬前列腺组织的二氢睾酮浓度：年龄和增生的影响。
影响因子：
4.8
作者：
Ewing,LL;Berry,SJ;Higginbottom,EG
通讯作者：
Higginbottom,EG