Blood flow in the human iris measured by laser Doppler flowmetry.

Blood flow in the human iris measured by laser Doppler flowmetry.
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通过激光多普勒血流计测量人体虹膜中的血流量。

DOI:
10.1006/mvre.1998.2136
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发表时间:
1999
影响因子:
3.1
通讯作者:
C. Riva
C. Riva
中科院分区:
医学3区
文献类型:
--
作者:
S. Chamot;A. Movaffaghy;B. Petrig;C. Riva

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基于激光多普勒血流仪(LDF)的一种新的仪器已被开发用于无创地测定红细胞(RBC)通过人眼虹膜微循环网络的相对流量。该方法所需的探测激光器、光电探测器和目标固定装置都适用于裂隙灯。多普勒信号的电子处理和计算机分析允许确定虹膜中RBC的相对速度、数量和流量,以及这些流动参数在心脏周期期间的脉动性。基于对八名正常志愿者的一只眼睛的测量,该技术的灵敏度,即,在P < 0.05的水平上可检测到的最小变化为通量的4%。响应于眼灌注压的降低的血流量的减少证明了该技术检测流量变化的能力及其用于研究虹膜循环的生理学和药理学的适用性。
A new instrument based on laser Doppler flowmetry (LDF) has been developed to determine noninvasively the relative flux of red blood cells (RBCs) through the microcirculatory network of the iris of the human eye. The probing laser, photodetector, and target fixation devices required by this method were adapted to a slit lamp. Electronic processing and computer analysis of the Doppler signal allow determination of relative velocity, number, and flux of RBCs in the iris, as well as the pulsatility of these flow parameters during the heart cycle. Based on measurements in one eye of eight normal volunteers, the sensitivity of the technique, i.e., the minimum change detectable at the P < 0.05 level, was 4% for the flux. The decrease in blood flow in response to decreases of the ocular perfusion pressure demonstrates the capability of the technique to detect flow changes and its suitability for investigating the physiology and the pharmacology of iris circulation.
DOI: 10.1016/s0161-6420(87)80009-x
发表时间: 1987
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