Grey wolf genomic history reveals a dual ancestry of dogs.
Grey wolf genomic history reveals a dual ancestry of dogs.
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灰狼的基因组历史揭示了狗的双重祖先。
DOI：
10.1038/s41586-022-04824-9
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发表时间：
2022-07
期刊：
影响因子：
64.8
通讯作者：
中科院分区：
文献类型：
--
作者：
灰狼（Canis lupus）是第一个产生家养种群的物种，在上一个冰河时代，当许多其他大型哺乳动物物种灭绝时，它们仍然广泛分布。然而，人们对过去狼种群的历史和可能灭绝的情况知之甚少，也不知道现在狗血统的狼祖先（Canis familiaris）生活在何时何地。在这里，我们分析了来自欧洲、西伯利亚和北美的72个古代狼的基因组，这些基因组跨越了过去10万年。我们发现，狼种群在整个晚更新世都是高度联系的，分化水平比今天低一个数量级。这种群体连接性使我们能够在整个时间序列中检测自然选择，包括在40，000 - 30，000年前快速固定基因IFT 88中的突变。我们发现，狗是整体更密切相关的古代狼从欧亚大陆东部比那些从欧亚大陆西部，这表明在东部的驯化过程。然而，我们还发现，近东和非洲的狗有一半的祖先来自与现代西南欧亚狼有关的独特种群，反映了独立的驯化过程或当地狼的混合物。没有一个分析过的古代狼基因组与这些狗的祖先直接匹配，这意味着确切的祖先种群仍然有待定位。来自10万年前古狼的DNA揭示了狼的进化历史和狗的基因组起源。
The grey wolf (Canis lupus) was the first species to give rise to a domestic population, and they remained widespread throughout the last Ice Age when many other large mammal species went extinct. Little is known, however, about the history and possible extinction of past wolf populations or when and where the wolf progenitors of the present-day dog lineage (Canis familiaris) lived. Here we analysed 72 ancient wolf genomes spanning the last 100,000 years from Europe, Siberia and North America. We found that wolf populations were highly connected throughout the Late Pleistocene, with levels of differentiation an order of magnitude lower than they are today. This population connectivity allowed us to detect natural selection across the time series, including rapid fixation of mutations in the gene IFT88 40,000–30,000 years ago. We show that dogs are overall more closely related to ancient wolves from eastern Eurasia than to those from western Eurasia, suggesting a domestication process in the east. However, we also found that dogs in the Near East and Africa derive up to half of their ancestry from a distinct population related to modern southwest Eurasian wolves, reflecting either an independent domestication process or admixture from local wolves. None of the analysed ancient wolf genomes is a direct match for either of these dog ancestries, meaning that the exact progenitor populations remain to be located. DNA from ancient wolves spanning 100,000 years sheds light on wolves’ evolutionary history and the genomic origin of dogs.
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影响因子：
56.9
作者：
Frantz, Laurent A. F.;Mullin, Victoria E.;Larson, Greger
通讯作者：
Larson, Greger
影响因子：
16.6
作者：
Botigué LR;Song S;Scheu A;Gopalan S;Pendleton AL;Oetjens M;Taravella AM;Seregély T;Zeeb-Lanz A;Arbogast RM;Bobo D;Daly K;Unterländer M;Burger J;Kidd JM;Veeramah KR
通讯作者：
Veeramah KR
影响因子：
9.8
作者：
Boyko AR;Quignon P;Li L;Schoenebeck JJ;Degenhardt JD;Lohmueller KE;Zhao K;Brisbin A;Parker HG;vonHoldt BM;Cargill M;Auton A;Reynolds A;Elkahloun AG;Castelhano M;Mosher DS;Sutter NB;Johnson GS;Novembre J;Hubisz MJ;Siepel A;Wayne RK;Bustamante CD;Ostrander EA
通讯作者：
Ostrander EA
DOI：
10.1126/science.1165448
发表时间：
2009-03-06
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Anderson TM;vonHoldt BM;Candille SI;Musiani M;Greco C;Stahler DR;Smith DW;Padhukasahasram B;Randi E;Leonard JA;Bustamante CD;Ostrander EA;Tang H;Wayne RK;Barsh GS
通讯作者：
Barsh GS
影响因子：
9.2
作者：
Chang CC;Chow CC;Tellier LC;Vattikuti S;Purcell SM;Lee JJ
通讯作者：
Lee JJ