Relation of serum osteocalcin level to risk of coronary heart disease in Chinese adults.
Relation of serum osteocalcin level to risk of coronary heart disease in Chinese adults.
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中国成人血清骨钙素水平与冠心病风险的关系
DOI：
10.1016/j.amjcard.2010.07.013
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发表时间：
2010-11
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影响因子：
--
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中科院分区：
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--
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骨钙素是一种骨源性多肽，最近被发现具有与代谢紊乱和动脉粥样硬化相关的激素功能。很少有研究研究循环中的骨钙素与冠心病(CHD)风险之间的关系。本研究的目的是调查血清骨钙素浓度是否与中国成年人的冠心病风险和代谢特征有关。共纳入461名接受冠状动脉造影的受试者(243名冠心病患者和218名非冠心病患者)。检测血清骨钙素、血糖、血脂和其他生化指标。冠状动脉粥样硬化的严重程度通过病变血管的数量来评估。结果表明，冠心病组血清骨钙素水平(12.2 ng/m l，9.5~15.1)显著低于非冠心病组(13.6 ng/m l，10.7~18.0，p=0.001)，并随病变血管数目的增加而显著降低(p=0.005)。调整冠心病状态后，血清骨钙素浓度与空腹和负荷后2小时血糖和血红蛋白A1c呈负相关(p分别为0.044、0.043和0.011)。血清骨钙素升高四分位数发生冠心病的优势比(95%可信区间)分别为0.68(0.42~1.12)、0.59(0.36~0.98)和0.40(0.23~0.69)。趋势检验意义重大(p=0.0007)。调整年龄、体重指数和其他传统的冠心病危险因素后，结果没有明显改变。样条线回归分析表明，血清骨钙素水平与冠心病风险呈线性关系。总之，我们的数据表明，血清骨钙素水平与中国成年人CHD风险的降低和保护性代谢变化有关。
Osteocalcin, a bone-derived polypeptide, was recently found to have hormonal function associated with metabolic disorders and atherosclerosis. Few studies have examined the association between circulating osteocalcin and coronary heart disease (CHD) risk. The aim of the present study was to investigate whether serum osteocalcin concentration was associated with CHD risk and metabolic profiles in Chinese adults. A total of 461 subjects (243 with CHD and 218 without CHD) who underwent coronary angiography were included. Serum osteocalcin, glucose, lipid profiles, and other biochemical markers were measured. Severity of coronary atherosclerosis was estimated by number of diseased vessels. Results showed that serum osteocalcin levels were significantly lower in the CHD group (12.2 ng/ml, 9.5 to 15.1) than in the non-CHD group (13.6 ng/ml, 10.7 to 18.0, p = 0.001) and were significantly decreased with the increasing of number of diseased vessels (p = 0.005). Serum osteocalcin concentration was inversely correlated with fasting and post load 2 hour plasma glucose and hemoglobin A1c(p = 0.044, 0.043, and 0.011, respectively), adjusting for CHD status. Odds ratios (95% confidence intervals) of CHD across increasing quartiles of serum osteocalcin were 0.68 (0.42 to 1.12), 0.59 (0.36 to 0.98), and 0.40 (0.23 to 0.69). The test for trend was significant (p = 0.0007). Adjusting for age, body mass index, and other conventional risk factors for CHD did not appreciably change the results. Spline regression analyses indicated a linear relation between serum osteocalcin level and CHD risk. In conclusion, our data indicate that serum osteocalcin level was associated with decreased risk of CHD and protective metabolic changes in Chinese adults.
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