Effects and Mechanisms of Probiotics, Prebiotics, Synbiotics, and Postbiotics on Metabolic Diseases Targeting Gut Microbiota: A Narrative Review.
Effects and Mechanisms of Probiotics, Prebiotics, Synbiotics, and Postbiotics on Metabolic Diseases Targeting Gut Microbiota: A Narrative Review.
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DOI：
10.3390/nu13093211
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发表时间：
2021-09-15
期刊：
影响因子：
5.9
通讯作者：
Li HB
中科院分区：
文献类型：
--
作者：
Li HY;Zhou DD;Gan RY;Huang SY;Zhao CN;Shang A;Xu XY;Li HB
代谢性疾病是严重威胁公众健康的疾病，与肠道微生物区系有关。益生元、益生元、合生元和生后元(PPSP)是肠道微生物区系的强大调节剂，因此在预防代谢性疾病方面具有广阔的前景。因此，PPSP在针对肠道微生物区系的代谢性疾病中的作用和机制值得探讨和阐明。总体而言，PPSP有利于代谢性疾病的管理，特别是肥胖症和2型糖尿病。肠道微生物相关机制主要是调节肠道微生物区系组成，调节肠道微生物代谢产物，改善肠道屏障功能。此外，临床试验表明，PPSP对代谢性疾病患者有好处，但治疗妊娠期糖尿病的临床策略、合生元的最佳配方和后生元的健康益处有待进一步研究。本文对益生元、益生元、合生元、后生元与代谢性疾病的关系进行了全面的综述，提出了有希望的结果和有争议的结果，并着重阐述了PPSP的可能机制和临床作用，以期对PPSP的进一步研究和开发有所帮助。
Metabolic diseases are serious threats to public health and related to gut microbiota. Probiotics, prebiotics, synbiotics, and postbiotics (PPSP) are powerful regulators of gut microbiota, thus possessing prospects for preventing metabolic diseases. Therefore, the effects and mechanisms of PPSP on metabolic diseases targeting gut microbiota are worth discussing and clarifying. Generally, PPSP benefit metabolic diseases management, especially obesity and type 2 diabetes mellitus. The underlying gut microbial-related mechanisms are mainly the modulation of gut microbiota composition, regulation of gut microbial metabolites, and improvement of intestinal barrier function. Moreover, clinical trials showed the benefits of PPSP on patients with metabolic diseases, while the clinical strategies for gestational diabetes mellitus, optimal formula of synbiotics and health benefits of postbiotics need further study. This review fully summarizes the relationship between probiotics, prebiotics, synbiotics, postbiotics, and metabolic diseases, presents promising results and the one in dispute, and especially attention is paid to illustrates potential mechanisms and clinical effects, which could contribute to the next research and development of PPSP.
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DOI：
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影响因子：
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