Capsinoids suppress fat accumulation via lipid metabolism.
Capsinoids suppress fat accumulation via lipid metabolism.
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Capsinoids 通过脂质代谢抑制脂肪积累
DOI：
10.3892/mmr.2014.2996
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发表时间：
2015-03
影响因子：
3.4
通讯作者：
Quan Y
中科院分区：
文献类型：
--
作者：
Hong Q;Xia C;Xiangying H;Quan Y
辣椒素是在红辣椒中发现的，据报道具有抗肥胖、抗高血压、抗糖尿病和抗炎的功能。在本研究中，我们确定了非刺激性辣椒酯类物质对脂肪细胞代谢的影响。我们证明了辣椒酯类化合物在体内和体外抑制小鼠的脂肪积累。肝脏是脂质代谢的主要组织，经辣椒酯类物质处理后，HMG-CoA还原酶、CPT-1、FAT/CD 36和GLUT 4均显著升高，表明辣椒酯类物质促进了肝脏和脂肪组织的脂质代谢。此外，通过添加辣椒酯类化合物，诱导的脂肪细胞还表现出HMG-CoA还原酶、CPT-1、FAT/CD 36和GLUT 4的水平显著增加。油红O染色也表明辣椒酯类物质减少脂肪细胞中的脂肪积累。总之，这些结果表明，辣椒酯类物质可能值得研究作为一种潜在的治疗肥胖。
Capsaicin, found in red peppers, has been reported to have anti-obesity, anti-hypertension, anti-diabetes and anti-inflammatory functions. In the present study, we determined the effect of non-pungent capsinoids on the metabolism of adipocytes. We demonstrated that capsinoids suppressed fat accumulation in vivo and in vitro in mice. Liver, the main tissue of lipid metabolism, was treated by capsinoids, and HMG-CoA reductase, CPT-1, FAT/CD36 and GLUT4 were found to be increased significantly, which demonstrated promotion of the lipid metabolism in liver and adipose tissues. In addition, by adding capsinoids, the induced adipocytes also demonstrated significantly increased levels of HMG-CoA reductase, CPT-1, FAT/CD36 and GLUT4. Oil red O staining also demonstrated that capsinoids decreased fat accumulation in the adipocytes. In conclusion, these results indicate that capsinoids may be worth investigating as a potential cure for obesity.
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影响因子：
1.6
作者：
Haramizu, S;Mizunoya, W;Fushiki, T
通讯作者：
Fushiki, T
DOI：
10.2183/pjab.79b.207
发表时间：
2003-09-01
影响因子：
3.1
作者：
Iwai, K;Yazawa, A;Watanabe, T
通讯作者：
Watanabe, T
影响因子：
82.9
作者：
Yamauchi, T;Kamon, J;Kadowaki, T
通讯作者：
Kadowaki, T
影响因子：
6.9
作者：
Kang, Ji-Hye;Tsuyoshi, Goto;Yu, Rina
通讯作者：
Yu, Rina
影响因子：
7.4
作者：
Lee, Eun-Jung;Jeon, Myung-Shin;Kim, Tae-Yoon
通讯作者：
Kim, Tae-Yoon