Associations between rotating night shifts, sleep duration, and telomere length in women.
Associations between rotating night shifts, sleep duration, and telomere length in women.
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DOI：
10.1371/journal.pone.0023462
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Han J
中科院分区：
文献类型：
--
作者：
Liang G;Schernhammer E;Qi L;Gao X;De Vivo I;Han J
端粒长度被认为是衰老的标志。然而，我们对决定端粒长度的生活方式风险因素的了解有限。我们评估了来自护士健康研究的4，117名女性参与者的夜班轮换年数，自我报告的睡眠时间和端粒长度之间的关联。采用Real-Time PCR法测定外周血白细胞端粒长度。在采血前通过问卷调查收集关于夜班轮换和睡眠持续时间的信息。我们使用多变量线性回归来研究夜班轮换、睡眠时间和端粒长度之间的关系。与该类别的女性（9小时）相比，在调整年龄，BMI和吸烟后，睡眠时间最短类别（≤6小时）的女性z评分降低了0.12个单位（相当于9年端粒磨损，趋势P = 0.05）。 在50岁以下的女性中观察到睡眠时间和端粒长度之间的显著正相关（趋势P = 0.004），但在50岁以上的女性中没有（趋势P = 0.33）（相互作用P = 0.005）。 此外，我们观察到，有较长的夜班轮换历史的女性倾向于具有较短的端粒长度，但这种关系在统计学上并不显著（趋势P = 0.36）。 我们发现，在50岁以下的女性中，睡眠时间与端粒长度呈正相关。需要进一步的研究来证实观察到的关联。
Telomere length has been proposed as a marker of aging. However, our knowledge of lifestyle risk factors determining telomere length is limited. We evaluated the associations between years of rotating night shifts, self-reported sleep duration, and telomere length in 4,117 female participants from the Nurses' Health Study. Telomere length in peripheral blood leukocytes was determined by Real-Time PCR assay. Information on rotating night shifts and sleep duration was collected via questionnaires prior to blood collection. We used multivariable linear regression to investigate the associations between rotating night shifts, sleep duration, and telomere length. Compared with women in the category (9 hours), those in the lowest category of sleep duration (≤6 hours) had a 0.12 unit decrease in z score after adjustment for age, BMI and cigarette smoking (equivalent to 9-year telomere attrition, P for trend = 0.05). Significant positive association between sleep duration and telomere length was seen among women under age of 50 (P for trend = 0.004), but not among those over 50 (P for trend = 0.33) (P for interaction = 0.005). In addition, we observed that women with a longer history of rotating night shifts tended to have shorter telomere length, but this relation was not statistically significant (P for trend = 0.36). We found that sleep duration was positively associated with telomere length among women under 50 years old. Further research is needed to confirm the observed associations.
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影响因子：
6.2
作者：
Prescott, Jennifer;McGrath, Monica;Lee, I-Min;Buring, Julie E.;De Vivo, Immaculata
通讯作者：
De Vivo, Immaculata
影响因子：
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