Phenotypic and genetic relationship between BMI and cigarette smoking in a sample of UK adults.

Phenotypic and genetic relationship between BMI and cigarette smoking in a sample of UK adults.
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英国成年人样本中体重指数与吸烟之间的表型和遗传关系。

DOI:
10.1016/j.addbeh.2018.09.025
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发表时间:
2019
影响因子:
4.4
通讯作者:
Hopfer,Christian
Hopfer,Christian
中科院分区:
医学2区
文献类型:
--
作者:
Wills,AmandaG;Hopfer,Christian

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除了吸烟和肥胖单独造成的健康危害外,这些情况的结合对健康造成了特别的损害。遗传因素已被证明会影响这两个特征,为了了解这些条件之间的联系,我们在英国的一个大样本中,研究了肥胖(体重指数(BMI)的电阻抗测量)和每天吸烟(CPD)之间的观察和遗传关系。在以前吸烟者中,BMI与以前吸烟的香烟呈正相关;此外,与吸烟数量更多相关的遗传因素也是BMI较高的原因。在目前的吸烟者中,BMI和吸烟数量之间存在正相关,尽管这种关系似乎不受类似遗传因素的影响。我们发现,当前/以前吸烟者的吸烟与从不吸烟者的BMI之间存在正遗传关系(这些人不会受到尼古丁的影响)。除了CPD,在目前的吸烟者中,我们还研究了两个变量,从醒来到第一支烟的时间和一天不吸烟的困难,这可能与香烟和食物的“渴望”更好地一致。然而,这些吸烟措施提供了混合的结果,就其与BMI的关系。总的来说,影响吸烟者CPD的遗传因素与影响前吸烟者和从不吸烟者BMI的遗传因素之间的正相关关系表明吸烟和肥胖背后的共同生物学影响。
In addition to the health hazards posed individually by cigarette smoking and obesity, the combination of these conditions poses a particular impairment to health. Genetic factors have been shown to influence both traits and, to understand the connection between these conditions, we examined both the observed and genetic relationship between adiposity (an electrical impedance measure of body mass index (BMI)) and cigarettes smoked per day (CPD) in a large sample of current, former, and never smokers in the United Kingdom. In former smokers, BMI was positively associated with cigarettes formerly smoked; further, the genetic factors related to a greater number of cigarettes smoked were also responsible for a higher BMI. In current smokers, there was a positive association between BMI and number of cigarettes smoked, though this relationship did not appear to be influenced by similar genetic factors. We found a positive genetic relationship between smoking in current/former smokers and BMI in never smokers (who would be unmarred by the effects of nicotine). In addition to CPD, in current smokers, we looked at two variables, time from waking to first cigarette and difficulty not smoking for a day, that may align better with cigarette and food ‘craving.’ However, these smoking measures provided mixed findings with respect to their relationship with BMI. Overall, the positive relationships between the genetic factors that influence CPD in smokers and the genetic factors that influence BMI in former and never smokers point to common biological influences behind smoking and obesity.
DOI: 10.1371/journal.pone.0123579
发表时间: 2015
期刊: PloS one
影响因子: 3.7
作者:
Dare S;Mackay DF;Pell JP
通讯作者: Pell JP
肥胖吸烟者是减烟政策中的潜在风险人群
DOI: --
发表时间: 2015
期刊: The Yale Journal of Biology and Medicine
影响因子: --
作者:
L. Rupprecht;E. Donny;A. Sved
通讯作者: A. Sved
DOI: 10.1007/3-540-29719-0_258
发表时间: 2020-02
期刊: Definitions
影响因子: --
作者:
Daniel Bell
通讯作者: Daniel Bell
DOI: 10.1038/nature14177
发表时间: 2015-02-12
期刊: NATURE
影响因子: 64.8
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发表时间: 2016-03-08
期刊: BMJ (Clinical research ed.)
影响因子: --
作者:
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