The menagerie of the basal forebrain: how many (neural) species are there, what do they look like, how do they behave and who talks to whom?
The menagerie of the basal forebrain: how many (neural) species are there, what do they look like, how do they behave and who talks to whom?
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DOI：
10.1016/j.conb.2017.05.004
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发表时间：
2017-06
影响因子：
5.7
通讯作者：
Brown RE
中科院分区：
文献类型：
--
作者：
Yang C;Thankachan S;McCarley RW;Brown RE
基底前脑的不同细胞类型控制着睡眠-觉醒状态、皮质活动和奖赏处理。大的、慢火的胆碱能神经元抑制皮质三角洲的活动，并促进皮质的可塑性，以响应增强剂。大的、快速放电的、皮质投射的GABA能神经元促进觉醒和快速的皮质活动。特别是，小白蛋白/GABA能神经元促进新皮质伽马带活动。相反，兴奋放电较慢的生长抑素/GABA能神经元通过抑制皮质投射神经元来促进睡眠。谷氨酸能神经元的激活可能通过兴奋其他皮质投射神经元来促进觉醒。同样，胆碱能神经元通过兴奋促进觉醒的皮质投射的GABA能神经元和/或抑制促进睡眠的生长抑素/GABA能神经元间接促进觉醒。在长时间的清醒状态下，胶质细胞和神经元都会增加腺苷的水平。腺苷突触前抑制谷氨酸能传入促进觉醒的胆碱能和GABA能/小蛋白神经元，促进睡眠。
The diverse cell-types of the basal forebrain control sleep-wake states, cortical activity and reward processing. Large, slow-firing, cholinergic neurons suppress cortical delta activity and promote cortical plasticity in response to reinforcers. Large, fast-firing, cortically-projecting GABAergic neurons promote wakefulness and fast cortical activity. In particular, parvalbumin/GABAergic neurons promote neocortical gamma band activity. Conversely, excitation of slower-firing somatostatin/GABAergic neurons promotes sleep through inhibition of cortically-projecting neurons. Activation of glutamatergic neurons promotes wakefulness, likely by exciting other cortically-projecting neurons. Similarly, cholinergic neurons indirectly promote wakefulness by excitation of wake-promoting, cortically-projecting GABAergic neurons and/or inhibition of sleep-promoting somatostatin/GABAergic neurons. Both glia and neurons increase the levels of adenosine during prolonged wakefulness. Adenosine presynaptically inhibits glutamatergic inputs to wake-promoting cholinergic and GABAergic/parvalbumin neurons, promoting sleep.
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影响因子：
3.7
作者：
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通讯作者：
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影响因子：
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作者：
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3.5
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