Regulation of average 24 h human plasma leptin level; the influence of exercise and physiological changes in energy balance
Regulation of average 24 h human plasma leptin level; the influence of exercise and physiological changes in energy balance
复制标题
人体24小时平均血浆瘦素水平的调节；运动和生理变化对能量平衡的影响；
DOI：
10.1038/sj.ijo.0800784
复制
发表时间：
1999
影响因子：
4.9
通讯作者：
W. Saris
中科院分区：
文献类型：
--
作者：
D. V. Aggel;M. Baak;R. Tenenbaum;L. Campfield;W. Saris
OBJECTIVE: The effects of short-term moderate physiological changes in energy flux and energy balance, by exercise and over- or underfeeding, on a 24 h plasma leptin profile, were investigated.DESIGN: Subjects were studied over 24 h in four randomized conditions: no exercise\energy balance (energy intake (EI)=;energy expenditure (EE)=;11.8±0.8 MJ); exercise\energy balance (EI=;EE=;15.1±0.6 MJ); exercise\negative energy balance (EI=;11.8±0.8 MJ, EE=;15.1±0.8 MJ); exercise\positive energy balance (EI=;18.6±0.7 MJ, EE=;15.1±0.6 MJ).SUBJECTS: Eight healthy, lean men (age: 23.5±7.0 y, body fat 14.1±5.4%, body mass index (BMI): 21.4±2.3 kg\m2).MEASUREMENTS: Blood was sampled every hour during the daytime (09.00–23.00 h) and every two hours during the night (01.00–09.00 h) for analysis of plasma leptin, insulin, glucose, FFA and catecholamines.RESULTS: Plasma leptin levels were highest around 01.00 h (mean±s.e.m. 4.9±2.0 ng\ml) and lowest around 11.00 h. (2.3±0.7 ng\ml). An increased 24 h EE, induced by exercise under conditions of energy balance, significantly decreased the peak and average 24 h plasma leptin concentration. A positive energy balance, by overfeeding, resulted in a significantly higher amplitude of the 24 h plasma leptin curve, compared to a condition of energy balance.CONCLUSION: Exercise decreases peak and average 24 h plasma leptin concentration and a moderately positive energy balance increases the amplitude of the 24 h plasma leptin profile. These effects are not acute, but are manifest within 24 h. The variations of average 24 h FFA and average 24 h glucose concentrations almost fully explained the variation in average 24 h leptin concentration across trials.
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影响因子：
15.9
作者：
Schoeller, DA;Cella, LK;Caro, JF
通讯作者：
Caro, JF
DOI：
10.1210/jcem.82.1.3840
发表时间：
1997
期刊：
The Journal of clinical endocrinology and metabolism.
影响因子：
--
作者：
Laughlin,GA;Yen,SS
通讯作者：
Yen,SS
影响因子：
15.9
作者：
Sinha, MK;Ohannesian, JP;Caro, JF
通讯作者：
Caro, JF
年轻女性体内脂肪的增加与夜间血清瘦素水平的升高呈负相关。
DOI：
10.1210/jcem.82.5.3917
发表时间：
1997
期刊：
The Journal of clinical endocrinology and metabolism.
影响因子：
--
作者：
Matkovic,V;Ilich,JZ;Badenhop,NE;Skugor,M;Clairmont,A;Klisovic,D;Landoll,JD
通讯作者：
Landoll,JD
DOI：
10.1006/bbrc.1996.1724
发表时间：
1996-11-21
影响因子：
3.1
作者：
Sinha, MK;Sturis, J;Caro, JF
通讯作者：
Caro, JF