Screening and diagnosis of gestational diabetes in India: a systematic review and meta-analysis.

Screening and diagnosis of gestational diabetes in India: a systematic review and meta-analysis.
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DOI:
10.1007/s00592-018-1131-1
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发表时间:
2018-06
期刊:
影响因子:
3.8
通讯作者:
Mathad JS
Mathad JS
中科院分区:
医学3区
文献类型:
--
作者:
Li KT;Naik S;Alexander M;Mathad JS

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尽管糖尿病在印度迅速增加,但对于妊娠期糖尿病(GDM)的筛查、诊断和管理的最佳实践,尚无全国性共识。这项研究的目的是系统地回顾印度妊娠期糖尿病的患病率和筛查和诊断方法的研究文献。我们检索了MEDLINE、Embase和POPLINE,以进行印度妊娠期糖尿病筛查的研究。我们收录了报告妊娠期糖尿病筛查方法和患病率的英文完整报告和横断面研究的会议摘要、前瞻性和回溯性队列。我们对所有研究进行描述性分析,对具有中低偏倚风险的研究进行Meta分析、Meta回归和亚组Meta分析。我们纳入了的研究,报告了90例患病率估计。患病率估计在0到41.9%之间。子集Meta分析显示,IADPSG诊断标准发现的妊娠期糖尿病病例(患病率=19.19%[15.5,23.6],p<0.05)显著高于WHO 1999标准(10.13%[8.17,12.50])和DIPSI标准(7.37%[5.2,10.16])。对IADPSG标准和世界卫生组织1999年标准进行比较的研究表明,肯定的符合率很低(33-79%)。明确GDM诊断时间的研究表明,GDM患者(11%-60%)早在妊娠早期就发展为GDM,但许多GDM病例(16%-40%)如果只在初诊时进行筛查就被漏掉了。在印度,妊娠期糖尿病的患病率估计因诊断标准的不同而有很大差异。在评估妊娠期糖尿病的筛查和诊断标准时,提供者应考虑患者的需求,并将筛查标准与妊娠结局相关联。
Although diabetes is rapidly increasing in India, there is no national consensus on best practices for screening, diagnosis, and management of gestational diabetes mellitus (GDM). The goal of this study was to systematically review the literature for studies reporting the prevalence and screening and diagnostic methods for gestational diabetes in India. We searched MEDLINE, Embase, and POPLINE for studies on screening for GDM in India. We included English-language full reports and conference abstracts of cross-sectional studies, prospective, and retrospective cohorts that reported the screening method and prevalence of GDM. We performed descriptive analysis on all studies and meta-analysis, meta-regression, and subgroup meta-analysis on studies with medium or low risk of bias. We included 64 studies reporting 90 prevalence estimates. Prevalence estimates ranged from 0 to 41.9%. Subset meta-analyses showed that the IADPSG diagnostic criteria found significantly more GDM cases (prevalence = 19.19% [15.5, 23.6], p < 0.05) than the WHO 1999 criteria (10.13% [8.17, 12.50]) and DIPSI criteria (7.37% [5.2, 10.16]). Studies that compared the IADPSG and WHO 1999 criteria showed poor positive agreement (33–79%). Studies specifying time of GDM diagnosis showed that patients (11–60%) develop GDM as early as the first trimester, but many GDM cases (16–40%) are missed if screened only at first visit. In India, prevalence estimates of GDM vary substantially by diagnostic criteria. When evaluating screening and diagnostic criteria for GDM, providers should consider their patients' needs and correlate screening criteria with pregnancy outcomes.
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