Snoring and aortic dimension in Marfan syndrome.
Snoring and aortic dimension in Marfan syndrome.
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DOI：
10.1007/s41105-022-00413-5
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发表时间：
2023
影响因子：
1.1
通讯作者：
中科院分区：
文献类型：
--
作者：
最近的报告表明，自我报告的鼾声是阻塞性睡眠呼吸暂停的一个特征，与马凡综合征(MFS)的主动脉增大有关。客观评估鼾症虽然缺乏，但可以为MFS患者的OSA筛查提供合理的依据。在这项研究中，我们的目标是检查MFS患者打鼾伴OSA的客观测量与主动脉大小之间的关联。约翰霍普金斯大学招募了报告打鼾症的连续MFS患者，完成了爱普沃斯嗜睡量表(ESS)，并接受了夜间多导睡眠图，期间捕捉到吸气声音。我们测量了呼吸的峰值分贝水平，鼾声被定义为流动限制，声音 ≥ 为40分贝(A)。将阻塞性睡眠呼吸暂停低通气指数定义为 ≥ 15或AHI：5-15和 >； 10。采用回归模型分析鼾气百分比与OSA和主动脉根部内径的关系。在我们的队列中(男性|女性：13|16，年龄：37.0 ± 15.5岁，主动脉直径；38.9 ± 4.8 mm)，在未调整(OR = 1.05，p = 0.040)模型和根据年龄和性别调整的模型(OR = 1.05，p = 0.048)中，鼾声呼吸百分比每增加1个单位，患阻塞性睡眠呼吸暂停的几率增加5%。同样，在未调整(β = 0.09，p = 0.007)和调整(β = 0.08，p = 0.023)模型中，鼾声呼吸百分比增加10个单位与同期主动脉根部直径增加1 mm相关。目的鼾症评估可以提供一种手段来识别需要睡眠检查的MFS患者，这些患者可能也有患更严重的主动脉疾病的风险。
Recent reports suggest that self-reported snoring, which is a feature of obstructive sleep apnea, is associated with aortic enlargement in Marfan syndrome (MFS). Objective assessment of snoring although lacking, could provide a rational for OSA screening in MFS patients. Our goal in this study was to examine the association between objective measurements of snoring with OSA and aortic size in persons with MFS. Consecutive persons with MFS who reported snoring were recruited at Johns Hopkins, completed the Epworth Sleepiness Scale (ESS) and underwent overnight polysomnography during which inspiratory sound was captured. We measured breath-by-breath peak decibel levels and snoring was defined as flow limitation with sound ≥ 40 dB(A). OSA was defined as an apnea–hypopnea-index (AHI) ≥ 15 or AHI: 5–15 and ESS > 10. Participants’ aortic data were collated to ascertain aortic root diameter. Regression models were used to determine the relationship of snoring breath% with OSA and aortic root diameter. In our cohort (M|F:13|16, Age: 37.0 ± 15.5 years, Aortic diameter; 38.9 ± 4.8 mm), a 1-unit increase in snoring breath percentage increased the odds of having OSA by 5% in both the unadjusted (OR = 1.05, p = 0.040) model, and a model adjusted for age and sex (OR = 1.05, p = 0.048). Similarly, a 10-unit increase in snoring breath percentage was associated with a 1 mm increase in contemporaneous aortic-root-diameter in both unadjusted (β = 0.09, p = 0.007), and adjusted (β = 0.08, p = 0.023) models. Objective snoring assessment could provide a means for identifying persons with MFS who need sleep studies, who may also be at risk for more severe aortic disease.
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影响因子：
4.1
作者：
Sowho M;MacCarrick G;Dietz H;Jun J;Schwartz AR;Neptune ER
通讯作者：
Neptune ER
影响因子：
2.8
作者：
Groth, Kristian A.;Stochholm, Kirstine;Gravholt, Claus H.
通讯作者：
Gravholt, Claus H.
影响因子：
3.1
作者：
Saeyeldin, Ayman;Zafar, Mohammad A.;Elefteriades, John A.
通讯作者：
Elefteriades, John A.
DOI：
10.1164/ajrccm/147.3.645
发表时间：
1993-03-01
期刊：
AMERICAN REVIEW OF RESPIRATORY DISEASE
影响因子：
--
作者：
CISTULLI, PA;SULLIVAN, CE
通讯作者：
SULLIVAN, CE
影响因子：
2.8
作者：
Devereux, Richard B.;de Simone, Giovanni;Arnett, Donna K.;Best, Lyle G.;Boerwinkle, Eric;Howard, Barbara V.;Kitzman, Lane;Lee, Elisa T.;Mosley, Thomas H., Jr.;Weder, Alan;Roman, Mary J.
通讯作者：
Roman, Mary J.