Sex differences in the association of prediabetes and type 2 diabetes with microvascular complications and function: The Maastricht Study.
Sex differences in the association of prediabetes and type 2 diabetes with microvascular complications and function: The Maastricht Study.
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DOI：
10.1186/s12933-021-01290-x
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发表时间：
2021-05-07
影响因子：
9.3
通讯作者：
Stehouwer CDA
中科院分区：
文献类型：
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作者：
de Ritter R;Sep SJS;van der Kallen CJH;van Greevenbroek MMJ;de Jong M;Vos RC;Bots ML;Reulen JPH;Houben AJHM;Webers CAB;Berendschot TTJM;Dagnelie PC;Eussen SJPM;Schram MT;Koster A;Peters SAE;Stehouwer CDA
女性2型糖尿病患者更容易出现大血管并发症；我们在这里调查了微血管并发症和视网膜微血管措施是否也是如此。在一项以人群为基础的队列研究中，年龄在40-75岁的个体（n = 3410, 49%为女性，29%为2型糖尿病（设计过采样）），我们估计了（前期）糖尿病（参考：正常葡萄糖代谢）、血糖持续测量与微血管并发症和视网膜测量（肾病、感觉神经病变、视网膜小动脉和静脉直径和扩张）之间的性别特异性关联及其差异。性别差异分析使用回归模型与相互作用项（即性别按（前）糖尿病和性别按血糖），并调整潜在的混杂因素。与葡萄糖代谢正常的男性（以及血糖水平较高的男性）相比，2型糖尿病男性（但不包括糖尿病前期患者）的肾病（优势比：1.58 95% CI(1.01;2.46)）和感觉神经病变（优势比：2.46(1.67;3.63)）的患病率明显更高，视网膜小动脉直径较大（差异：4.29µm(1.22;7.36)），视网膜小动脉扩张较小（差异：- 0.74%(- 1.22;- 0.25)）。在女性中，这些关联在数字上是相同的，但通常没有统计学意义(优势比：1.71（0.90;3.25）和1.22 (0.75;1.98)；差异:0.29µm(−3.50;4.07)和:分别−0.52%(−1.11;0.08))。相互作用分析显示，在糖尿病前期或2型糖尿病或血糖与微血管并发症或视网膜测量的关联中，没有一致的性别差异模式。晚期并发症的发生率太低，无法评估。我们的研究结果表明，女性2型糖尿病患者早期微血管并发症的影响并不大。在线版本包含补充材料，可在10.1186/s12933-021-01290-x获得。
Women with type 2 diabetes are disproportionally affected by macrovascular complications; we here investigated whether this is also the case for microvascular complications and retinal microvascular measures. In a population-based cohort study of individuals aged 40–75 years (n = 3410; 49% women, 29% type 2 diabetes (oversampled by design)), we estimated sex-specific associations, and differences therein, of (pre)diabetes (reference: normal glucose metabolism), and of continuous measures of glycemia with microvascular complications and retinal measures (nephropathy, sensory neuropathy, and retinal arteriolar and venular diameters and dilatation). Sex differences were analyzed using regression models with interaction terms (i.e. sex-by- (pre)diabetes and sex-by-glycemia) and were adjusted for potential confounders. Men with type 2 diabetes (but not those with prediabetes) compared to men with normal glucose metabolism, (and men with higher levels of glycemia), had significantly higher prevalences of nephropathy (odds ratio: 1.58 95% CI (1.01;2.46)) and sensory neuropathy (odds ratio: 2.46 (1.67;3.63)), larger retinal arteriolar diameters (difference: 4.29 µm (1.22;7.36)) and less retinal arteriolar dilatation (difference: − 0.74% (− 1.22; − 0.25)). In women, these associations were numerically in the same direction, but generally not statistically significant (odds ratios: 1.71 (0.90;3.25) and 1.22 (0.75;1.98); differences: 0.29 µm (− 3.50;4.07) and: − 0.52% (− 1.11;0.08), respectively). Interaction analyses revealed no consistent pattern of sex differences in the associations of either prediabetes or type 2 diabetes or glycemia with microvascular complications or retinal measures. The prevalence of advanced-stage complications was too low for evaluation. Our findings show that women with type 2 diabetes are not disproportionately affected by early microvascular complications. The online version contains supplementary material available at 10.1186/s12933-021-01290-x.
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影响因子：
4.3
作者：
Kajiwara A;Kita A;Saruwatari J;Miyazaki H;Kawata Y;Morita K;Oniki K;Yoshida A;Jinnouchi H;Nakagawa K
通讯作者：
Nakagawa K
影响因子：
--
作者：
Kamenov, Zdravko Asenov;Parapunova, Rumyana Atanasova;Georgieva, Rumyana Taneva
通讯作者：
Georgieva, Rumyana Taneva
影响因子：
16.2
作者：
Coopmans, Charlotte;Zhou, Tan Lai;Stehouwer, Coen D. A.
通讯作者：
Stehouwer, Coen D. A.
1型和2型糖尿病青年糖尿病周围神经病的患病率和危险因素：青年研究中寻找糖尿病。
影响因子：
16.2
作者：
Jaiswal M;Divers J;Dabelea D;Isom S;Bell RA;Martin CL;Pettitt DJ;Saydah S;Pihoker C;Standiford DA;Dolan LM;Marcovina S;Linder B;Liese AD;Pop-Busui R;Feldman EL
通讯作者：
Feldman EL
影响因子：
8.8
作者：
通讯作者：
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