In the View of Endothelial Microparticles: Novel Perspectives for Diagnostic and Pharmacological Management of Cardiovascular Risk during Diabetes Distress.
In the View of Endothelial Microparticles: Novel Perspectives for Diagnostic and Pharmacological Management of Cardiovascular Risk during Diabetes Distress.
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DOI：
10.1155/2018/9685205
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发表时间：
2018
影响因子：
4.3
通讯作者：
Gomes MS
中科院分区：
文献类型：
--
作者：
Pernomian L;Moreira JD;Gomes MS
急性或慢性暴露于糖尿病相关的应激源会引发一种特殊的心理和行为应激综合征，称为糖尿病痛苦，这是大多数糖尿病患者抑郁症状的基础。苦恼和/或抑郁的糖尿病成人表现出较高的心血管死亡率和发病率，这与糖尿病行为应激诱发的大血管并发症有关。最近的实验结果清楚地指出，氧化应激占血管功能障碍所引发的暴露于生活应激源在糖尿病条件。此外，氧化应激已被描述为糖尿病受试者中由内皮微粒（从受损内皮细胞释放的无核外体微泡）诱导的心血管损伤的主要自分泌和旁分泌机制。氧化应激和心血管疾病之间的这种强有力的关系强烈表明内皮微粒作为氧化还原依赖性血管功能障碍的基础糖尿病痛苦的引物信使的关键作用。在这里，我们提供了新的观点，开放的观点内皮微粒作为有前途的诊断和药理学生物标志物的心血管疾病的风险，在痛苦的糖尿病患者。
Acute or chronic exposure to diabetes-related stressors triggers a specific psychological and behavior stress syndrome called diabetes distress, which underlies depressive symptoms in most diabetic patients. Distressed and/or depressive diabetic adults exhibit higher rates of cardiovascular mortality and morbidity, which have been correlated to macrovascular complications evoked by diabetic behavior stress. Recent experimental findings clearly point out that oxidative stress accounts for the vascular dysfunction initiated by the exposure to life stressors in diabetic conditions. Moreover, oxidative stress has been described as the main autocrine and paracrine mechanism of cardiovascular damage induced by endothelial microparticles (anuclear ectosomal microvesicles released from injured endothelial cells) in diabetic subjects. Such robust relationship between oxidative stress and cardiovascular diseases strongly suggests a critical role for endothelial microparticles as the primer messengers of the redox-dependent vascular dysfunction underlying diabetes distress. Here, we provide novel perspectives opened in the view of endothelial microparticles as promising diagnostic and pharmacotherapeutic biomarkers of cardiovascular risk in distressed diabetic patients.
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