Bile Acid Regulates the Colonization and Dissemination of Candida albicans from the Gastrointestinal Tract by Controlling Host Defense System and Microbiota.
Bile Acid Regulates the Colonization and Dissemination of Candida albicans from the Gastrointestinal Tract by Controlling Host Defense System and Microbiota.
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DOI：
10.3390/jof7121030
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发表时间：
2021-11-30
期刊：
影响因子：
--
通讯作者：
Guo GL
中科院分区：
文献类型：
--
作者：
Thangamani S;Monasky R;Lee JK;Antharam V;HogenEsch H;Hazbun TR;Jin Y;Gu H;Guo GL
白色念珠菌（CA）是一种共生和机会性真核生物，经常栖息在胃肠道（GI）并引起危及生命的感染。抗生素诱导的肠道生态失调是CA从胃肠道定植和传播增加的主要危险因素。我们发现牛磺胆酸（TCA）显著增加，这是抗生素治疗小鼠易受CA感染的一种主要胆汁酸。体内研究结果表明，通过饮用水给药TCA足以诱导CA在野生型和免疫抑制小鼠体内定植和传播。TCA治疗可显著降低结肠中免疫基因ang4和Cxcr3的mRNA表达。此外，TCA显著降低了盲肠内容物和结肠粘膜刮擦物中三种可培养的共生细菌——血Turicibacter sanguinis、约氏乳杆菌（Lactobacillus johnsonii）和梭状芽胞杆菌（Clostridium celatum）的相对丰度。综上所述，我们的研究结果表明，TCA通过控制宿主防御系统和肠道微生物群，促进真菌定植和CA从胃肠道传播，而宿主防御系统和肠道微生物群在调节肠道CA中起关键作用。
Candida albicans (CA), a commensal and opportunistic eukaryotic organism, frequently inhabits the gastrointestinal (GI) tract and causes life-threatening infections. Antibiotic-induced gut dysbiosis is a major risk factor for increased CA colonization and dissemination from the GI tract. We identified a significant increase of taurocholic acid (TCA), a major bile acid in antibiotic-treated mice susceptible to CA infection. In vivo findings indicate that administration of TCA through drinking water is sufficient to induce colonization and dissemination of CA in wild-type and immunosuppressed mice. Treatment with TCA significantly reduced mRNA expression of immune genes ang4 and Cxcr3 in the colon. In addition, TCA significantly decreased the relative abundance of three culturable species of commensal bacteria, Turicibacter sanguinis, Lactobacillus johnsonii, and Clostridium celatum, in both cecal contents and mucosal scrapings from the colon. Taken together, our results indicate that TCA promotes fungal colonization and dissemination of CA from the GI tract by controlling the host defense system and intestinal microbiota that play a critical role in regulating CA in the intestine.
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影响因子：
4.5
作者：
Enaud R;Vandenborght LE;Coron N;Bazin T;Prevel R;Schaeverbeke T;Berger P;Fayon M;Lamireau T;Delhaes L
通讯作者：
Delhaes L
对真菌病原体的先天防御。
影响因子：
5.4
作者：
Drummond RA;Gaffen SL;Hise AG;Brown GD
通讯作者：
Brown GD
影响因子：
64.8
作者：
Devkota, Suzanne;Wang, Yunwei;Musch, Mark W.;Leone, Vanessa;Fehlner-Peach, Hannah;Nadimpalli, Anuradha;Antonopoulos, Dionysios A.;Jabri, Bana;Chang, Eugene B.
通讯作者：
Chang, Eugene B.
影响因子：
12.6
作者：
Ciorba, Matthew A.
通讯作者：
Ciorba, Matthew A.
DOI：
10.1007/978-3-319-04220-6_4
发表时间：
2014-01-01
期刊：
INFECTIOUS COMPLICATIONS IN CANCER PATIENTS
影响因子：
--
作者：
Angarone, Michael
通讯作者：
Angarone, Michael