Comprehensive analysis of the clinical significance and prospective molecular mechanisms of differentially expressed autophagy-related genes in thyroid cancer.
Comprehensive analysis of the clinical significance and prospective molecular mechanisms of differentially expressed autophagy-related genes in thyroid cancer.
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DOI：
10.3892/ijo.2018.4404
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发表时间：
2018-08
影响因子：
5.2
通讯作者：
Chen G
中科院分区：
文献类型：
--
作者：
Lin P;He Y;Wen DY;Li XJ;Zeng JJ;Mo WJ;Li Q;Peng JB;Wu YQ;Pan DH;Li HY;Mo QY;Wei YP;Yang H;Chen G
甲状腺癌（TC）是最常见的内分泌系统恶性肿瘤，约占所有内分泌系统恶性肿瘤的90%。尽管事实上，TC患者往往有良好的预后，高发病率和淋巴结转移仍然是未解决的问题。自噬是维持细胞内稳态不可或缺的过程;然而，自噬在TC的起始和进展的几个步骤中的作用尚未阐明。在这项研究中，我们首先确定了几个自噬相关基因（ARGs），在TC的发病引起的。随后，生物信息学分析提示，这些基因在几个增殖信号通路中受到明显干扰。此外，我们发现差异表达的ARGs与一些侵袭性临床表现密切相关，包括晚期肿瘤分期和淋巴结转移。我们的研究进一步选择了预后ARG，并开发了基于三个关键基因（ATG 9 B，BID和B1 DNAJB 1）的预后标志，这些基因显示出中等的预测TC预后的能力。总的来说，这项研究的结果表明，ARGs破坏增殖相关的途径，从而导致积极的临床表现。这些发现提供了对ARG作用的潜在分子机制及其临床意义的深入了解，并提供了具有潜在治疗意义的分类信息。
Thyroid cancer (TC) is the most common endocrine malignancy, accounting for approximately 90% of all malignancies of the endocrine system. Despite the fact that patients with TC tend to have good prognoses, the high incidence rate and lymph node metastases remain unresolved issues. Autophagy is an indispensable process that maintains intracellular homeostasis; however, the role of autophagy in several steps of the initiation and progression of TC has not yet been elucidated. In this study, we first identified several autophagy-related genes (ARGs) that were provoked in the onset of TC. Subsequently, a bioinformatics analysis hinted that these genes were markedly disturbed in several proliferative signaling pathways. Moreover, we demonstrated that the differentially expressed ARGs were closely related to several aggressive clinical manifestations, including an advanced tumor stage and lymph node metastasis. Our study further selected prognostic ARGs and developed a prognostic signature based on three key genes (ATG9B, BID and B1DNAJB1), which displayed a moderate ability to predict the prognosis of TC. On the whole, the findings of this study demonstrate that ARGs disrupt proliferation-related pathways and consequently lead to aggressive clinical manifestations. These findings provide insight into the potential molecular mechanisms of action of ARGs and their clinical significance, and also provide classification information of potential therapeutic significance.
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影响因子：
7.3
作者：
Gao J;Aksoy BA;Dogrusoz U;Dresdner G;Gross B;Sumer SO;Sun Y;Jacobsen A;Sinha R;Larsson E;Cerami E;Sander C;Schultz N
通讯作者：
Schultz N
DOI：
10.1111/febs.14388
发表时间：
2018-05
期刊：
The FEBS journal
影响因子：
--
作者：
Mowers EE;Sharifi MN;Macleod KF
通讯作者：
Macleod KF
影响因子：
10.5
作者：
Guo, Jessie Yanxiang;Chen, Hsin-Yi;White, Eileen
通讯作者：
White, Eileen
影响因子：
120.7
作者：
Bibbins-Domingo, Kirsten;Grossman, David C.;Tseng, Chien-Wen
通讯作者：
Tseng, Chien-Wen
影响因子：
5.2
作者：
Paquette M;El-Houjeiri L;Pause A
通讯作者：
Pause A