Behavioral differences between late preweanling and adult female Sprague-Dawley rat exploration of animate and inanimate stimuli and food.
Behavioral differences between late preweanling and adult female Sprague-Dawley rat exploration of animate and inanimate stimuli and food.
复制标题
DOI：
10.1016/j.bbr.2010.10.038
复制
发表时间：
2011-03-01
影响因子：
2.7
通讯作者：
Morrell, Joan I.
中科院分区：
文献类型：
--
作者：
Smith, Kiersten S.;Morrell, Joan I.
晚期断奶前大鼠具有作为最初在幼儿期表现出的病症的临床前模型的潜力，所述病症的特征在于与特定刺激（例如，强迫症和自闭症）。然而，在文献中没有发现特定的刺激探索在后期断奶前大鼠。我们研究了正常晚期断奶前（PND 18-19）和成年大鼠的行为反应时，提出的样本分类不同的刺激，包括无生命的物体系统地改变大小和相互作用的特性，生物刺激，和食物。断奶前更快地启动特定的刺激探索，并与大多数特定的刺激比成人更互动，这些断奶前成人的数量差异的幅度范围从相当小到非常大，这取决于刺激。相比之下，断奶前的成年人一样，在他们的相互作用与食物和猎物。断奶前的反应，一些刺激，例如活的小狗，是从成人的性质不同，断奶前的行为剧目的特点是小狗寻求，而成人的反应的特点是小狗回避。特定的刺激相互作用的断奶前的影响比成年人的测试和放置在一个焦虑的刺激位置的一天的时间。新奇的影响是刺激依赖的。断奶前与成年动物与特定刺激物的相互作用的差异表明，这些行为模式背后的CNS系统在PND 18时处于不同的不成熟阶段，因此可能存在各种类别的特定刺激物的一系列发育轨迹。这些数据提供了一个基础，使用的断奶前作为一个临床前模型的理解和药物治疗人类疾病的发展过程中，其特征是与特定的刺激功能失调的相互作用。
The late preweanling rat has potential as a preclinical model for disorders initially manifested in early childhood that are characterized by dysfunctional interactions with specific stimuli (e.g., obsessive-compulsive disorder and autism). No reports, however, of specific-stimulus exploration in the late preweanling rat are found in the literature. We examined the behavioral responses of normal late preweanling (PND 18-19) and adult rats when presented with exemplars of categorically-varied stimuli, including inanimate objects systematically varied in size and interactive properties, biological stimuli, and food. Preweanlings were faster to initiate specific stimulus exploration and were more interactive with most specific stimuli than adults; the magnitude of these preweanling-adult quantitative differences ranged from fairly small to very large depending upon the stimulus. In contrast, preweanlings were adult-like in their interaction with food and prey. Preweanling response to some stimuli, for example to live pups, was qualitatively different from that of adults; the preweanling behavioral repertoire was characterized by pup-seeking while the adult response was characterized by pup-avoidance. The specific stimulus interactions of preweanlings were less impacted than those of adults by the time of day of testing and placement of a stimulus in an anxiety-provoking location. The impact of novelty was stimulus dependent. The differences in interactions of preweanlings versus adults with specific stimuli suggests that CNS systems underlying these behavior patterns are at different stages of immaturity at PND 18 such that there may be an array of developmental trajectories for various categories of specific stimuli. These data provide a basis for the use of the preweanling as a preclinical model for understanding and medicating human disorders during development that are characterized by dysfunctional interactions with specific stimuli.
登录
查看更多内容
影响因子：
2.5
作者：
BOLLES, RC;WOODS, PJ
通讯作者：
WOODS, PJ
影响因子：
2.7
作者：
Comoli, E;Ribeiro-Barbosa, ER;Canteras, NS
通讯作者：
Canteras, NS
DOI：
10.1037/h0026344
发表时间：
1968-01-01
期刊：
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
ADER, R
通讯作者：
ADER, R
DOI：
10.1111/j.1096-3642.1975.tb00265.x
发表时间：
1975-01-01
影响因子：
2.8
作者：
COWAN, PE;BARNETT, SA
通讯作者：
BARNETT, SA
影响因子：
1.9
作者：
Burns, LH;Annett, L;Robbins, TW
通讯作者：
Robbins, TW