General and social anxiety in the BTBR T+ tf/J mouse strain.
General and social anxiety in the BTBR T+ tf/J mouse strain.
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DOI：
10.1016/j.bbr.2010.08.039
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发表时间：
2011-01-01
影响因子：
2.7
通讯作者：
Blanchard, Robert J.
中科院分区：
文献类型：
--
作者：
Pobbe, Roger L. H.;Defensor, Erwin B.;Pearson, Brandon L.;Bolivar, Valerie J.;Blanchard, D. Caroline;Blanchard, Robert J.
BTBR T+ tf/J（BTBR）是一种近交系小鼠品系，其表现出与自闭症谱系障碍（ASD）的三种诊断症状相似的行为特征;社交互动缺陷，沟通障碍和兴趣受限的重复行为。先前的研究结果表明，与C57 BL/6 J（B6）和其他近交系相比，BTBR在设计用于评估焦虑相关行为的范式中表现出正常至低焦虑样特征。目前的研究评估了这些焦虑发现的普遍性。实验一采用B6和BTBR小鼠进行高架十字迷宫、小鼠防御成套测验和高架零迷宫测试。与B6相比，BTBR小鼠表现出焦虑的特征，开放臂时间减少，风险评估行为增加。在MDTB中，BTBR表现出增强的发声捕食者，并显着较少的运动活动比B6在威胁前的情况下，但显着更多的运动比B6暴露于捕食者的威胁，这表明增强防御的捕食者。在零迷宫中，与B6相比，BTBR小鼠显示出显著更高的进入次数和在装置的开放段中花费的时间。在实验2中，使用三腔社会偏好测试来评估全身给予抗焦虑化合物地西泮对B6和BTBR社交方式的影响。地西泮持续增加B6和BTBR小鼠在含有社会刺激的隔室中的时间。然而，在溶剂处理组中，B6小鼠在社交刺激室中花费的时间显著更多，而BTBR小鼠在社交刺激室中花费的时间显著更少;在地西泮给药后，B6和BTBR品系均显著偏好社交刺激室。这些结果表明，虽然BTBR小鼠对新情况（迷宫和零迷宫）的焦虑反应是不一致的，但BTBR小鼠似乎对动画威胁刺激（捕食者或另一只小鼠）更具防御性。在三室试验中，地西泮减少焦虑使BTBR对小鼠刺激的社会偏好正常化。
BTBR T+ tf/J (BTBR) is an inbred mouse strain that shows behavioral traits with analogies to the three diagnostic symptoms of autism spectrum disorder (ASD); deficits in social interaction, impaired communication, and repetitive behaviors with restricted interests. Previous findings reveal that when compared to C57BL/6J (B6) and other inbred strains, BTBR exhibit normal to low anxiety-like traits in paradigms designed to assess anxiety-related behaviors. The current study assessed the generality of these anxiety findings. In experiment 1, B6 and BTBR mice were tested in the elevated plus maze (EPM), mouse defense test battery (MDTB) and elevated zero-maze. BTBR mice exhibited an anxiogenic profile in the EPM, with a reduction in open arm time and an increase in risk assessment behaviors, as compared to B6. In the MDTB, BTBR showed enhanced vocalization to the predator, and significantly less locomotor activity than B6 in the pre-threat situation, but significantly more locomotion than B6 following exposure to a predator threat, suggesting enhanced defensiveness to the predator. In the zero-maze, BTBR mice showed a significantly higher number of entries and time spent in the open segments of the apparatus, when compared to B6. In experiment 2, a three-chambered social preference test was used to evaluate effects of the systemic administration of an anxiolytic compound, diazepam, on B6 and BTBR social approach. Diazepam consistently increased time in the compartment containing the social stimulus, for both B6 and BTBR mice. However, in the vehicle treated groups, B6 mice spent significantly more time while BTBR mice spent significantly less time in the social stimulus compartment; after diazepam administration both B6 and BTBR strains significantly preferred the social stimulus chamber. These results suggest that while the anxiety responses of BTBR mice to novel situations (EPM and zero-maze) are inconsistent, BTBR mice appear to be more defensive to animate threat stimuli (predator or another mouse). Reduction of anxiety by diazepam normalized the social preference of BTBR for a mouse stimulus in the three-chambered test.
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影响因子：
4.5
作者：
Fombonne E;Heavey L;Smeeth L;Rodrigues LC;Cook C;Smith PG;Meng L;Hall AJ
通讯作者：
Hall AJ
影响因子：
6.9
作者：
BAILEY, A;LECOUTEUR, A;RUTTER, M
通讯作者：
RUTTER, M
影响因子：
2.7
作者：
Brodkin, Edward S.
通讯作者：
Brodkin, Edward S.
影响因子：
3.4
作者：
Bleickardt, C. J.;Mullins, D. E.;Hodgson, R. A.
通讯作者：
Hodgson, R. A.
影响因子：
8.2
作者：
Blanchard, DC;Griebel, G;Blanchard, RJ
通讯作者：
Blanchard, RJ