The effect of contact angles and capillary dimensions on the burst frequency of super hydrophilic and hydrophilic centrifugal microfluidic platforms, a CFD study.
The effect of contact angles and capillary dimensions on the burst frequency of super hydrophilic and hydrophilic centrifugal microfluidic platforms, a CFD study.
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DOI：
10.1371/journal.pone.0073002
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Madou MJ
中科院分区：
文献类型：
--
作者：
Kazemzadeh A;Ganesan P;Ibrahim F;He S;Madou MJ
本文采用流体体积（VOF）方法数值研究了离心微流体系统中超亲水和亲水毛细管阀的宽度、高度和接触角对突发频率的影响。文献中现有的实验结果已用于验证数值方法的实施。研究了超亲水离心微流平台上矩形和圆形微流结构中毛细管阀的性能。数值结果还与现有的理论模型进行了比较，并讨论了差异。我们的实验和计算结果显示方形毛细管处出现最小突发频率，该结果对于设计和开发更复杂的毛细管阀网络很有用。它还预测，在超亲水微流体中，流体在低压下持续从毛细管阀泄漏，这可能会破坏离心微流体平台中的生物医学程序。
This paper employs the volume of fluid (VOF) method to numerically investigate the effect of the width, height, and contact angles on burst frequencies of super hydrophilic and hydrophilic capillary valves in centrifugal microfluidic systems. Existing experimental results in the literature have been used to validate the implementation of the numerical method. The performance of capillary valves in the rectangular and the circular microfluidic structures on super hydrophilic centrifugal microfluidic platforms is studied. The numerical results are also compared with the existing theoretical models and the differences are discussed. Our experimental and computed results show a minimum burst frequency occurring at square capillaries and this result is useful for designing and developing more sophisticated networks of capillary valves. It also predicts that in super hydrophilic microfluidics, the fluid leaks consistently from the capillary valve at low pressures which can disrupt the biomedical procedures in centrifugal microfluidic platforms.
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