Absence of Visual Input Results in the Disruption of Grid Cell Firing in the Mouse.
Absence of Visual Input Results in the Disruption of Grid Cell Firing in the Mouse.
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DOI：
10.1016/j.cub.2016.06.043
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发表时间：
2016-09-12
期刊：
影响因子：
9.2
通讯作者：
Wills, Thomas Joseph
中科院分区：
文献类型：
--
作者：
Chen, Guifen;Manson, Daniel;Cacucci, Francesca;Wills, Thomas Joseph
网格细胞是位于内嗅皮层的空间调节神经元，其放电场分布在等边三角形的顶点上。它们发射的精细周期性使人们认为它们代表了一种路径整合信号，通过整合运动的速度和方向来跟踪生物体的位置。需要外部感官输入来重置路径积分器不可避免地积累的任何错误。在这里，我们通过记录小鼠在完全黑暗中探索熟悉环境时的网格细胞，来探索维持网格放电所需的外部感觉输入的本质。视觉线索的缺失导致网格细胞放电模式的严重破坏，即使头部方向细胞提供的定向信息的质量在很大程度上得到了保留。黑暗改变了内嗅皮层内速度信号的表达，网格细胞放电率和局部场电位θ频率的变化明显。网格细胞对之间的短期（<1.5 s）峰值时间关系在黑暗中被保留，这表明网格细胞之间的兴奋性和抑制性耦合的网络模式独立于视觉输入和空间周期性放电而存在。然而，在相当短的时间尺度内，我们没有发现在单个网格细胞的空间放电中保留六边形对称性的证据。综上所述，这些结果表明，视觉输入是维持小鼠网格细胞周期性和稳定性所必需的，并且表明小鼠网格细胞在缺乏可靠的视觉线索的情况下无法进行准确的路径整合。在小鼠中，网格细胞的放电模式在黑暗中被破坏，即使头部方向的细胞信号被保留，网格细胞也会被破坏。缺乏视觉输入改变了θ频率的运动速度调制，网格细胞对之间的时间放电关系在黑暗中被保留。Chen等人在小鼠中表明，缺乏视觉输入导致网格细胞放电严重中断。这不是由航向信号不稳定引起的，而可能是由于速度信号的改变。即使网格细胞的空间放电模式被破坏，它们之间的时间放电关系也被保留了下来。
Grid cells are spatially modulated neurons within the medial entorhinal cortex whose firing fields are arranged at the vertices of tessellating equilateral triangles. The exquisite periodicity of their firing has led to the suggestion that they represent a path integration signal, tracking the organism’s position by integrating speed and direction of movement. External sensory inputs are required to reset any errors that the path integrator would inevitably accumulate. Here we probe the nature of the external sensory inputs required to sustain grid firing, by recording grid cells as mice explore familiar environments in complete darkness. The absence of visual cues results in a significant disruption of grid cell firing patterns, even when the quality of the directional information provided by head direction cells is largely preserved. Darkness alters the expression of velocity signaling within the entorhinal cortex, with changes evident in grid cell firing rate and the local field potential theta frequency. Short-term (<1.5 s) spike timing relationships between grid cell pairs are preserved in the dark, indicating that network patterns of excitatory and inhibitory coupling between grid cells exist independently of visual input and of spatially periodic firing. However, we find no evidence of preserved hexagonal symmetry in the spatial firing of single grid cells at comparable short timescales. Taken together, these results demonstrate that visual input is required to sustain grid cell periodicity and stability in mice and suggest that grid cells in mice cannot perform accurate path integration in the absence of reliable visual cues. Grid cell firing patterns are disrupted in darkness in the mouse Grid cells are disrupted even when head direction cell signaling is preserved Absence of visual input alters movement velocity modulation of theta frequency Temporal firing relationships between grid cell pairs are preserved in the dark Chen et al. show in the mouse that lack of visual input results in severe disruption of grid cell firing, and that this is not caused by instability in the head direction signal but may be due to changed velocity signaling. Temporal firing relationships between grid cells are preserved, even when their spatial firing patterns are disrupted.
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影响因子：
1.2
作者：
Raudies, Florian;Mingolla, Ennio;Hasselmo, Michael E.
通讯作者：
Hasselmo, Michael E.
影响因子：
3.5
作者：
Wills TJ;Barry C;Cacucci F
通讯作者：
Cacucci F
影响因子：
2.9
作者：
Kadir SN;Goodman DF;Harris KD
通讯作者：
Harris KD
DOI：
10.1016/j.cub.2015.08.034
发表时间：
2015-10-05
期刊：
Current biology : CB
影响因子：
--
作者：
Winter SS;Mehlman ML;Clark BJ;Taube JS
通讯作者：
Taube JS
影响因子：
25
作者：
Bonnevie, Tora;Dunn, Benjamin;Moser, May-Britt
通讯作者：
Moser, May-Britt