The tumour-stromal interaction between intratumoral c-Met and stromal hepatocyte growth factor associated with tumour growth and prognosis in non-small-cell lung cancer patients.
The tumour-stromal interaction between intratumoral c-Met and stromal hepatocyte growth factor associated with tumour growth and prognosis in non-small-cell lung cancer patients.
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DOI：
10.1038/sj.bjc.6601718
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发表时间：
2004-04-19
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
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应用免疫组织化学方法检测88例非小细胞肺癌(NSCLC)中肝细胞生长因子(HGF)和c-Met表达对肿瘤生长和血管生成的影响。HGF阳性22例(25.0%)，间质HGF阳性14例(15.9%)，癌内c-Met阳性36例(40.9%)。无一例癌间质c-Met阳性。肿瘤生长检测显示，间质肝细胞生长因子阳性肿瘤中Ki-67指数高的肿瘤发生率显著高于间质肝细胞生长因子阴性肿瘤(P=0.0197)。C-Met阳性肿瘤中Ki-67指数高的肿瘤发生率也显著高于c-Met阴性肿瘤(P=0.0301)。然而，肿瘤血管与瘤内HGF状态、间质HGF状态和c-Met状态之间没有显著差异。C-Met阳性肿瘤患者的生存率明显低于c-Met阴性肿瘤患者(P=0.0095)。C-Met阳性肿瘤和间质HGF阳性肿瘤患者的生存率均显著低于阳性肿瘤患者和两种阴性肿瘤患者(P=0.0183和P=0.0011)。单因素分析显示，肿瘤内c-Met表达是影响非小细胞肺癌患者预后的重要因素(相对危险度=2.642，P=0.0029)。本研究表明，肿瘤细胞来源的c-Met和基质细胞来源的HGF之间的肿瘤-间质相互作用影响NSCLC患者的肿瘤生长和预后。
Immunohistochemical analyses of the effects of hepatocyte growth factor (HGF) and c-Met expression on tumour growth and angiogenesis were performed on 88 patients with non-small-cell lung cancers (NSCLCs). In all, 22 carcinomas (25.0%) were intratumoral HGF-positive, 14 carcinomas (15.9%) were stromal HGF-positive, and 36 carcinomas (40.9%) were intratumoral c-Met-positive. None of the carcinomas were stromal c-Met-positive. Examination of tumour growth revealed that the frequency of tumours with a high Ki-67 index was significantly greater for stromal HGF-positive tumours than for stromal HGF-negative tumours (P=0.0197). The frequency of tumours with a high Ki-67 index was also significantly greater for intratumoral c-Met-positive tumours than for intratumoral c-Met-negative tumours (P=0.0301). However, there was no significant difference in tumour vascularity with relation to intratumoral HGF status, stromal HGF status, and intratumoral c-Met status. The survival rate of patients with intratumoral c-Met-positive tumours was significantly lower than for patients with c-Met-negative tumours (P=0.0095). Furthermore, the survival rate of patients with both intratumoral c-Met-positive and stromal HGF-positive tumours was significantly lower than for patients with either positive tumours, and that of patients with both negative tumours (P=0.0183 and P=0.0011, respectively). A univariate analysis revealed that intratumoral c-Met expression was a significant prognostic factor of NSCLC patients (relative risk=2.642, P=0.0029). The present study demonstrates that tumour–stromal interaction between tumour cell-derived c-Met and stromal cell-derived HGF affects tumour growth and the prognosis of NSCLC patients.
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影响因子：
64.8
作者：
NAKAMURA, T;NISHIZAWA, T;SHIMIZU, S
通讯作者：
SHIMIZU, S
影响因子：
56.9
作者：
BOTTARO, DP;RUBIN, JS;AARONSON, SA
通讯作者：
AARONSON, SA
影响因子：
4.6
作者：
Matsuyama, K;Chiba, Y;Tanigawa, N
通讯作者：
Tanigawa, N
DOI：
10.1111/j.1349-7006.1996.tb03111.x
发表时间：
1996-10-01
期刊：
JAPANESE JOURNAL OF CANCER RESEARCH
影响因子：
--
作者：
Ichimura, E;Maeshima, A;Nakamura, T
通讯作者：
Nakamura, T
影响因子：
2.2
作者：
Edakuni, G;Sasatomi, E;Miyazaki, K
通讯作者：
Miyazaki, K