Association of COVID-19 Lockdown With Gestational Diabetes Mellitus.
Association of COVID-19 Lockdown With Gestational Diabetes Mellitus.
复制标题
COVID-19 封锁与妊娠期糖尿病的关联
DOI：
10.3389/fendo.2022.824245
复制
发表时间：
2022
影响因子：
5.2
通讯作者：
Liu T
中科院分区：
文献类型：
--
作者：
He Z;Lv Y;Zheng S;Pu Y;Lin Q;Zhou H;Dong M;Wang J;Fan J;Ye Y;Chen H;Qian R;Jin J;Chen Y;Chen G;He G;Cheng S;Hu J;Xiao J;Ma W;Su X;Liu T
持续的COVID-19大流行仍在影响着我们的生活，但封锁措施对孕妇妊娠期糖尿病（GDM）的影响尚不清楚。调查COVID-19封锁与GDM之间的关系。提取广东省5家医院2015-2020年140844例孕妇病历。在怀孕期间经历COVID-19一级封锁（2020年1月23日至2月24日）的孕妇被定义为暴露组（N=20472），在2015-2019年（1月23日至2月24日）经历相同日历月的孕妇被定义为未暴露组（N=120372）。采用亚组分析方法探索COVID-19封锁对GDM的潜在易感暴露窗口。通过对不同暴露强度的反应期分配不同的权重来定量估计累积暴露。使用逻辑回归模型估计COVID-19封锁暴露与GDM之间的关联。暴露组和未暴露组GDM发生率分别为15.2%和12.4%。总体分析显示，在所有孕妇中，封锁暴露与GDM风险呈正相关（比值比，OR=1.22, 95%CI: 1.17, 1.27）。在怀孕头四个月接受COVID-19封锁的女性中发现了更明显的关联，调整后的OR值在5-8孕周（GWs）的女性中为1.24 (95%CI: 1.10, 1.39)，在< 5孕周的女性中为1.35 （95%CI: 1.20, 1.52）。此外，我们发现累积封锁暴露与GDM风险呈正相关。COVID-19封锁与GDM风险增加有关，怀孕的头四个月可能是敏感接触的窗口期。
The ongoing pandemic of COVID-19 is still affecting our life, but the effects of lockdown measures on gestational diabetes mellitus (GDM) in pregnant women remain unclear. To investigate the association between COVID-19 lockdown and GDM. Medical records of 140844 pregnant women during 2015-2020 were extracted from 5 hospitals in Guangdong Province, China. Pregnant women who underwent the COVID-19 Level I lockdown (1/23 - 2/24/2020) during pregnancy were defined as the exposed group (N=20472) and pregnant women who underwent the same calendar months during 2015-2019 (1/23 - 2/24) were defined as the unexposed group (N=120372). Subgroup analyses were used to explore the potential susceptible exposure window of COVID-19 lockdown on GDM. Cumulative exposure is quantitatively estimated by assigning different weights to response periods with different exposure intensities. A logistic regression model was used to estimate the association between COVID-19 lockdown exposure and GDM. The rates of GDM in the exposed and unexposed groups were 15.2% and 12.4%, respectively. The overall analyses showed positive associations (odds ratio, OR=1.22, 95%CI: 1.17, 1.27) between lockdown exposure and GDM risk in all pregnant women. More pronounced associations were found in women who underwent the COVID-19 lockdown in their first four months of pregnancy, and the adjusted OR values ranged from 1.24 (95%CI: 1.10, 1.39) in women with 5-8 gestational weeks (GWs) to 1.35 (95%CI: 1.20, 1.52) with < 5 GWs. In addition, we found a positive exposure-response association of cumulative lockdown exposure with the risk of GDM. The COVID-19 lockdown was associated with an increased risk of GDM, and the first four months of pregnancy may be the window for sensitive exposure.
登录
查看更多内容
影响因子：
7.2
作者：
Ghesquière L;Garabedian C;Drumez E;Lemaître M;Cazaubiel M;Bengler C;Vambergue A
通讯作者：
Vambergue A
影响因子：
3.2
作者：
Gao C;Sun X;Lu L;Liu F;Yuan J
通讯作者：
Yuan J
影响因子：
5.1
作者：
Agarwal, Mukesh M.;Boulvain, Michel;Samad, Noorjahan
通讯作者：
Samad, Noorjahan
影响因子：
2.3
作者：
Leppanen, Marja;Aittasalo, Minna;Luoto, Riitta
通讯作者：
Luoto, Riitta
DOI：
10.3390/ijerph16193720
发表时间：
2019-10-01
影响因子：
--
作者：
Abdo, Mona;Ward, Isabella;Crooks, James L.
通讯作者：
Crooks, James L.