PET Hypometabolism of the Prefrontal-Cingulate Cortices in Internet Gaming Disorder.
PET Hypometabolism of the Prefrontal-Cingulate Cortices in Internet Gaming Disorder.
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DOI：
10.3389/fpsyt.2020.566518
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发表时间：
2020
影响因子：
4.7
通讯作者：
Chung YA
中科院分区：
文献类型：
--
作者：
Kim SK;Jeong H;Im JJ;Lee SH;Chung YA
最近，过度和不受控制地使用网络游戏已被公认为公众关注的问题。虽然以前的神经影像学研究已经报道了网络游戏障碍（IGD）的结构和功能性脑缺陷，但很少有研究调查了局部脑葡萄糖代谢率（rCMRglu）。本研究使用18 F-FDG PET（18 F-fluoro-2-deoxyglucose positron emission tomography，18 F-FDG PET）研究了IGD患者和健康对照者之间rCMRglu的差异。共有23名IGD成人和23名对照者接受了脑18F-FDG PET扫描并完成了自我报告问卷。对rCMRglu进行全脑体素分析，并评估rCMRglu与IGD严重程度之间的相关性。IGD组比对照组表现出更高的冲动性（p = 0.04）和更低的自我控制（p = 0.002）。此外，IGD组左侧内侧眶额回、左侧扣带回中部、左侧上级额回和右侧扣带回前部的FDG摄取较低（p < 0.001）。在右前扣带回皮质中的rCMRglu与满足IGD诊断标准的数量之间发现了显著的负相关性（β =-0.50，p = 0.02）。我们的研究结果表明，IGD可能与赤字的葡萄糖代谢在前额叶扣带皮层。
Recently, excessive and uncontrolled use of online games has been recognized as a public concern. Although previous neuroimaging studies have reported structural and functional brain deficits in Internet gaming disorder (IGD), very few studies have investigated the regional cerebral metabolic rate of glucose (rCMRglu). This study investigated the differences in rCMRglu between individuals with IGD and healthy controls using 18F-fluoro-2-deoxyglucose positron emission tomography (18F-FDG PET). A total of 23 adults with IGD and 23 controls underwent brain 18F-FDG PET scans and completed self-report questionnaires. A whole-brain voxel-wise analysis of rCMRglu was conducted and associations between rCMRglu and severity of IGD were assessed. The IGD group showed higher impulsivity (p = 0.04) and lower self-control (p = 0.002) than the control group. In addition, the IGD group had lower FDG uptake in the left medial orbitofrontal gyrus, left middle cingulate cortex, left superior frontal gyrus, and right anterior cingulate cortex (p < 0.001). A significant negative association was found between the rCMRglu in the right anterior cingulate cortex and the number of fulfilled diagnostic criteria for IGD (β = −0.50, p = 0.02). Our results suggest that IGD may be associated with deficits of glucose metabolism in the prefrontal-cingulate cortices.
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影响因子：
3.7
作者：
Kim YI;Kim HS;Park JW
通讯作者：
Park JW
DOI：
10.3390/ijerph15040668
发表时间：
2018-04-03
影响因子：
--
作者：
González-Bueso V;Santamaría JJ;Fernández D;Merino L;Montero E;Ribas J
通讯作者：
Ribas J
DOI：
10.1016/j.pnpbp.2019.109680
发表时间：
2019-12-20
影响因子：
5.6
作者：
Kim, Heejung;Kim, Yu Kyeong;Choi, Jung-Seok
通讯作者：
Choi, Jung-Seok
DOI：
10.3390/ijerph15010040
发表时间：
2018-01-01
影响因子：
--
作者：
Rho, Mi Jung;Lee, Hyeseon;Choi, In Young
通讯作者：
Choi, In Young
影响因子：
14.5
作者：
Berlin, HA;Rolls, ET;Kischka, U
通讯作者：
Kischka, U