The exercise metabolome: acute aerobic and anaerobic signatures.
The exercise metabolome: acute aerobic and anaerobic signatures.
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DOI：
10.1080/15502783.2022.2115858
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发表时间：
2022
影响因子：
5.1
通讯作者：
Arent SM
中科院分区：
文献类型：
--
作者：
Pellegrino JK;Anthony TG;Gillies P;Arent SM
锻炼方式不同地改变了身体成分和体能表现。这些结果背后的代谢变化可以通过评估循环代谢物来追踪。在这里，利用基于发现的代谢组学平台，比较了男性和女性受试者血清中对急性有氧运动或无氧运动的整体反应。在不同的几天，40名健康、活跃的参与者完成45分钟的有氧自行车或阻力运动，并在休息时、运动后即刻(T1)和运动后1小时(T2)采集血样，以检测血清代谢情况。在这个健康的队列中，这两种运动代谢物似乎更相似，而不是不同。总体而言，两种运动方式的代谢特征在T1时显著改变，并在T2时恢复到基线水平。有氧自行车运动后T1的代谢扰动和运动后的T1-T2恢复率大于阻力运动。共有的特征包括嘌呤代谢、底物分解代谢和动员以及炎症信号的升高。有氧运动导致更多的底物多样性和脂肪酸的使用，而抗阻运动表现出更高的嘌呤周转和糖酵解通量。不同条件下的代谢物在大小上存在差异，但在方向上没有差异。在不同的运动方式中，运动反应的代谢特征似乎相当强健。最初的不安和运动后一小时后恢复的趋势定义了我们健康队列中的特征。有氧循环后的加速恢复可能是由整体脂代谢升高所致。
Exercise modality differentially alters body composition and physical performance. Metabolic changes underlying these outcomes can be tracked through assessment of circulating metabolites. Here, global responses to an acute bout of aerobic or anaerobic exercise were compared in the serum of male and female subjects using a discovery-based metabolomics platform. On separate days, 40 healthy, active participants completed 45 min of aerobic cycling or resistance exercise, and blood samples were collected at rest, immediately after (T1) and 1 hour post-exercise (T2) to examine the serum metabolomic landscape. The two exercise metabolomes appeared more similar than different in this healthy cohort. Overall, metabolomic signatures of both exercise modalities were markedly altered from rest at T1, and returned toward baseline by T2. Metabolomic perturbations at T1 and the T1-T2 rate of recovery post-exercise were greater following aerobic cycling than resistance exercise. Shared signatures included elevations in purine metabolism, substrate catabolism and mobilization, and inflammatory signaling. Aerobic exercise resulted in greater substrate diversity and use of fatty acids, whereas resistance exercise displayed higher purine turnover and glycolytic flux. Individual metabolite differences between conditions were seen in magnitude but not direction. Metabolomic signatures of the exercise responses appeared fairly robust across exercise modalities. An initial perturbation and subsequent shift toward recovery by an hour post-exercise defined the signature in our healthy cohort. The expedited recovery following aerobic cycling may be explained by globally elevated lipid metabolism.
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影响因子：
3.7
作者：
Mukherjee K;Edgett BA;Burrows HW;Castro C;Griffin JL;Schwertani AG;Gurd BJ;Funk CD
通讯作者：
Funk CD
DOI：
10.2174/2213235x03666150211000831
发表时间：
2014-01-01
期刊：
CURRENT METABOLOMICS
影响因子：
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作者：
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通讯作者：
Watson, David G.
影响因子：
2.7
作者：
Lee, Sang-Rok;Khamoui, Andy V.;Kim, Jeong-Su
通讯作者：
Kim, Jeong-Su
影响因子：
4.4
作者：
Nieman, David C.;Shanely, R. Andrew;Lila, Mary Ann
通讯作者：
Lila, Mary Ann
DOI：
10.1186/s12970-017-0189-4
发表时间：
2017
影响因子：
5.1
作者：
Kerksick CM;Arent S;Schoenfeld BJ;Stout JR;Campbell B;Wilborn CD;Taylor L;Kalman D;Smith-Ryan AE;Kreider RB;Willoughby D;Arciero PJ;VanDusseldorp TA;Ormsbee MJ;Wildman R;Greenwood M;Ziegenfuss TN;Aragon AA;Antonio J
通讯作者：
Antonio J