Can Resistance Exercise Alter Irisin Levels and Expression Profiles of FNDC5 and UCP1 in Rats?
Can Resistance Exercise Alter Irisin Levels and Expression Profiles of FNDC5 and UCP1 in Rats?
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抗阻运动能否改变大鼠体内鸢尾素水平以及 FNDC5 和 UCP1 的表达谱？
DOI：
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发表时间：
2016
影响因子：
--
通讯作者：
S. Marandi
中科院分区：
文献类型：
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作者：
J. Reisi;K. Ghaedi;H. Rajabi;S. Marandi
背景鸢尾素是一种新的骨骼肌分泌的肌因子，对脂肪组织的代谢有重要影响。目的运动训练发挥其益处的细胞和分子鉴定机制仍不清楚，正在调查中。方法观察8周抗阻运动对雄性大鼠血浆鸢尾素水平及肌肉FNDC 5和皮下脂肪组织UCP 1表达谱的影响。16只成年雄性大鼠分为对照组（n = 8）和运动训练组（n = 8）。训练组在特定的梯子（120 cm高）上接受3天/周的锻炼，其负荷为体重的50%，该梯子连接到它们的尾巴上。结果在训练过程中，负荷量逐渐增加，最后一周达到大鼠体重的200%。有三组，每组五次重复，每组锻炼之间休息3分钟，重复之间休息1分钟。评估血浆鸢尾素水平和基因UCP 1和FNDC 5的相对mRNA表达。结果显示，抗阻运动8周后，大鼠血浆中鸢尾素水平显著升高（P < 0.001，t = 4.48）。FNDC 5（P < 0.001，t = 6.18）和UCP 1（P < 0.001，t = 13.91）基因的相对表达量也显著增加。结论抗阻运动可能通过增加白色脂肪组织中鸢尾素的分泌而促进脂肪组织产热，从而改善机体组成。
Background Irisin is a new myokine secreted from the skeletal muscle and appears to affect the metabolism of adipose tissue. Objectives The mechanisms of cellular and molecular identification by which exercise training exerts its benefits remain unclear and are under investigation. Methods We examined the effect of 8-week resistance exercise on plasma irisin levels and expression profiles of muscle FNDC5 and subcutaneous adipose tissue UCP1 in male rats. Sixteen adult male rats were divided into two groups, control (n = 8) and exercise training (n = 8) groups. The training group received exercise for 3 days/week on a specific ladder (120 cm height) with a carrying load of 50% of body weight, which was attached to their tails. Results The weight of the load was gradually increased during the training sessions, ultimately reaching 200% of the body weight of rats in the final week. There were three sets of five repetitions with a 3-min rest between each set of exercise sessions and 1 minute between repetitions. Plasma irisin levels and relative mRNA expression of the genes UCP1 and FNDC5 were assessed. The results demonstrated a significant increase in the irisin levels after 8 weeks of resistance exercise (P < 0.001, t = 4.48). The relative expression of FNDC5 (P < 0.001, t = 6.18) and UCP1 genes (P < 0.001, t = 13.91) was also significantly increased. Conclusions Therefore, we can conclude from this study that resistance exercise may improve body composition possibly through increased thermogenesis in white adipose tissue through the secretion of irisin.
影响因子：
9.8
作者：
Muenzberg, Heike;Morrison, Christopher D.
通讯作者：
Morrison, Christopher D.
阻力训练量、能量平衡和体重管理：9 个月试验的原理和设计。
影响因子：
2.2
作者：
Washburn,RichardA;Donnelly,JosephE;Smith,BryanK;Sullivan,DebraK;Marquis,Janet;Herrmann,StephenD
通讯作者：
Herrmann,StephenD
DOI：
10.1152/ajpregu.00806.2010
发表时间：
2011-05-01
影响因子：
2.8
作者：
Xu, Xiaohua;Ying, Zhekang;Sun, Qinghua
通讯作者：
Sun, Qinghua