Expression and molecular profiles of the AlkB family in ovarian serous carcinoma.
Expression and molecular profiles of the AlkB family in ovarian serous carcinoma.
复制标题
AlkB 家族在卵巢浆液性癌中的表达和分子谱。
DOI：
10.18632/aging.202716
复制
发表时间：
2021-03-19
期刊：
影响因子：
--
通讯作者：
Xu Z
中科院分区：
文献类型：
--
作者：
Cai Y;Wu G;Peng B;Li J;Zeng S;Yan Y;Xu Z
铁（II）和α-酮戊二酸依赖双加氧酶的AlkB家族在卵巢浆液性癌（OV）的发展中起重要作用。然而，在OV中，AlkB家族的分子谱尚未明确。结果表明，ALKBH1/3/5/8和FTO在OV患者中表达较低，而ALKBH2/4/6/7表达较高。ALKBH5/7与OV患者的病理分期有很强的相关性。Kaplan-Meier绘图图显示，高ALKBH4水平的OV患者总生存期（OS）更长。然而，高水平ALKBH5/6和FTO患者的OS和无进展生存期（PFS）较短。使用cBioPortal进行遗传改变的结果显示，FTO的变异率最高。我们还发现，AlkB家族的功能与几种癌症相关的信号通路有关，包括趋化因子受体信号通路。TIMER数据库显示，AlkB家族与六种免疫细胞（巨噬细胞、中性粒细胞、CD8+ t细胞、b细胞、CD4+ t细胞和树突状细胞）的浸润有很强的关系。接下来，疾病eth数据库显示，OV患者的ALKBH1/2/3/4/5/6/7/8和FTO的整体甲基化水平均较低。因此，我们的研究结果将增强对AlkB家族在OV病理中的认识，并为OV患者的AlkB靶向治疗提供新的见解。
AlkB family of Fe (II) and α-ketoglutarate-dependent dioxygenases plays essential roles in development of ovarian serous carcinoma (OV). However, the molecular profiles of AlkB family in OV have not been clarified. The results indicated that the expression of ALKBH1/3/5/8 and FTO was lower in OV patients while ALKBH2/4/6/7 expression was higher. There was a strong correlation between ALKBH5/7 and pathological stage of OV patients. Kaplan-Meier plotter revealed that OV patients with high ALKBH4 level showed longer overall survival (OS). However, patients with high levels of ALKBH5/6 and FTO showed shorter OS and progression-free survival (PFS). Genetic alterations using cBioPortal revealed that the alteration rates of FTO were the highest. We also found that the functions of AlkB family were linked to several cancer-associated signaling pathways, including chemokine receptor signaling. TIMER database indicated that the AlkB family had a strong relationship with the infiltration of six types of immune cells (macrophages, neutrophils, CD8+ T-cells, B-cells, CD4+ T-cells and dendritic cells). Next, DiseaseMeth databases revealed that the global methylation levels of ALKBH1/2/3/4/5/6/7/8 and FTO were all lower in OV patients. Thus, our findings will enhance the understanding of AlkB family in OV pathology, and provide novel insights into AlkB-targeted therapy for OV patients.
登录
查看更多内容
影响因子：
14.9
作者：
The Gene Ontology Consortium
通讯作者：
The Gene Ontology Consortium
影响因子：
4.7
作者：
Ferraresi A;Girone C;Esposito A;Vidoni C;Vallino L;Secomandi E;Dhanasekaran DN;Isidoro C
通讯作者：
Isidoro C
影响因子：
5.3
作者：
Jiang, Yi;Wan, Yicong;Cheng, Wenjun
通讯作者：
Cheng, Wenjun
m6A 修饰与癌症之间的联系
影响因子：
5.7
作者：
Liu ZX;Li LM;Sun HL;Liu SM
通讯作者：
Liu SM
GEPIA2：用于大规模表达谱和交互式分析的增强型 Web 服务器
影响因子：
14.9
作者：
Tang, Zefang;Kang, Boxi;Zhang, Zemin
通讯作者：
Zhang, Zemin