Association between resistin and fibroblast growth factor 23 in patients with type 2 diabetes mellitus.
Association between resistin and fibroblast growth factor 23 in patients with type 2 diabetes mellitus.
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DOI：
10.1038/s41598-018-32432-z
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发表时间：
2018-09-18
影响因子：
4.6
通讯作者：
Yokoo T
中科院分区：
文献类型：
--
作者：
Nakashima A;Yokoyama K;Kawanami D;Ohkido I;Urashima M;Utsunomiya K;Yokoo T
成纤维细胞生长因子23（FGF 23）与糖尿病患者的心血管疾病和全因死亡率相关。最近有报道称，胰岛素抵抗会增加FGF 23水平，而FGF 23是一种主要调节胰岛素抵抗的肽。然而，很少有研究调查FGF 23和Escherichia coli之间的关联。共有422名糖尿病患者被招募进行这项横断面研究，以检查β-淀粉样蛋白和完整的FGF 23之间的关联。平均（±标准差）年龄为63.1 ± 11.9岁，中位HbA 1c为6.7%（范围：6.1-7.1%）。平均估计肾小球滤过率（eGFR）为66.2 ± 23.1 mL/min/m2。多元回归分析显示，logFGF 23（系数（Coef）：1.551;标准误（SE）：0.739; P = 0.036），C-肽（Coef：0.798; SE：0.229; P = 0.001），ghrelin（Coef：1.061; SE：0.332; P = 0.001），全段甲状旁腺激素（Coef：0.022; SE：0.099; P = 0.030）和eGFR（Coef：-0.091; SE：0.017; P < 0.001）均与β-内酰胺酶水平显著相关。这些相关性在年龄较大、体重指数较低和维生素D水平较高的患者中有所改变。这些结果表明，血清FGF 23水平与β-氨基丁酸呈正相关。
Fibroblast growth factor 23 (FGF23) is associated with cardiovascular disease and all-cause mortality in patients with diabetes mellitus. Insulin resistance has recently been reported to increase FGF23 levels, and resistin is a peptide that mainly regulates insulin resistance. However, few studies have investigated the association between FGF23 and resistin. A total of 422 patients with diabetes mellitus were recruited for this cross-sectional study to examine the association between resistin and intact FGF23. The mean ( ± standard deviation) age was 63.1 ± 11.9 years, and the median HbA1c was 6.7% (range, 6.1–7.1%). The mean estimated glomerular filtration rate (eGFR) was 66.2 ± 23.1 mL/min/m2. Multiple regression analysis for resistin showed that logFGF23 (coefficient (Coef): 1.551; standard error (SE): 0.739; P = 0.036), C-peptide (Coef: 0.798; SE: 0.229; P = 0.001), ghrelin (Coef: 1.061; SE: 0.332; P = 0.001), intact parathyroid hormone (Coef: 0.022; SE: 0.099; P = 0.030), and eGFR (Coef: −0.091; SE: 0.017; P < 0.001) were all significantly associated with the resistin level. These associations were modified in patients with higher age, lower body mass index, and higher vitamin D levels. These results suggest that resistin is positively associated with serum FGF23 levels.
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影响因子：
16.2
作者：
Jain SH;Massaro JM;Hoffmann U;Rosito GA;Vasan RS;Raji A;O'Donnell CJ;Meigs JB;Fox CS
通讯作者：
Fox CS
DOI：
10.1056/nejmoa0706130
发表时间：
2008-08-07
期刊：
The New England journal of medicine
影响因子：
--
作者：
Gutiérrez OM;Mannstadt M;Isakova T;Rauh-Hain JA;Tamez H;Shah A;Smith K;Lee H;Thadhani R;Jüppner H;Wolf M
通讯作者：
Wolf M
影响因子：
19.6
作者：
Axelsson, J;Bergsten, A;Stenvinkel, P
通讯作者：
Stenvinkel, P
影响因子：
4.5
作者：
Berndt, Theresa J.;Craig, Theodore A.;Kumar, Rajiv
通讯作者：
Kumar, Rajiv
影响因子：
3.7
作者：
Hanks LJ;Casazza K;Judd SE;Jenny NS;Gutiérrez OM
通讯作者：
Gutiérrez OM