Cross-sectional associations between abdominal and thoracic adipose tissue compartments and adiponectin and resistin in the Framingham Heart Study.
Cross-sectional associations between abdominal and thoracic adipose tissue compartments and adiponectin and resistin in the Framingham Heart Study.
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DOI：
10.2337/dc08-1733
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发表时间：
2009-05
期刊：
影响因子：
16.2
通讯作者：
Fox CS
中科院分区：
文献类型：
--
作者：
Jain SH;Massaro JM;Hoffmann U;Rosito GA;Vasan RS;Raji A;O'Donnell CJ;Meigs JB;Fox CS
检测局部脂肪沉积与循环脂联素和脂联素浓度的相关性，并评估脂肪因子对腹部脂肪沉积与心脏代谢危险因素之间相关性的潜在介导作用。无心血管疾病的Frachial Heart研究后代队列（n = 916，55%为女性;平均年龄59岁）的参与者接受了内脏脂肪组织（VAT）、皮下脂肪组织（SAT）、心包脂肪和胸内脂肪体积的计算机断层扫描测量以及循环脂联素和脂联素测定。VAT、SAT、心包脂肪、胸内脂肪与脂联素呈负相关（r =-0.19至-0.34，P < 0.001 [女性]; r =-0.15至-0.26，P < 0.01 [男性]，SAT除外），并与平均年龄呈正相关。（r = 0.16-0.21，P < 0.001 [女性]; r = 0.11-0.14，P < 0.05 [男性]，不包括VAT）。VAT将脂联素的多变量模型R2从2-4%增加到10-13%，将β-内酰胺酶的多变量模型R2从3-4%增加到3- 6%。对脂肪因子的调整并没有完全减弱增值税、SAT和心脏代谢风险因素之间的关联。脂联素和脂联素在横截面上与脂肪库相关，但没有一种脂肪因子可以作为脂肪库的替代物。VAT、SAT和心脏代谢危险因素之间的关系不能完全用脂联素或脂联素浓度来解释。
To test the association of regional fat depots with circulating adiponectin and resistin concentrations and to assess the potential mediating effect of adipokines on associations between abdominal fat depots and cardiometabolic risk factors. Participants from the Framingham Heart Study offspring cohort (n = 916, 55% women; mean age 59 years) free of cardiovascular disease underwent computed tomography measurement of visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), pericardial fat, and intrathoracic fat volumes and assays of circulating adiponectin and resistin. VAT, SAT, pericardial fat, and intrathoracic fat were negatively correlated with adiponectin (r = −0.19 to −0.34, P < 0.001 [women]; r = −0.15 to −0.26, P < 0.01 [men] except SAT) and positively correlated with resistin (r = 0.16–0.21, P < 0.001 [women]; r = 0.11–0.14, P < 0.05 [men] except VAT). VAT increased the multivariable model R2 for adiponectin from 2–4% to 10–13% and for resistin from 3–4% to 3–6%. Adjustment for adipokines did not fully attenuate associations between VAT, SAT, and cardiometabolic risk factors. Adiponectin and resistin are correlated with fat depots cross-sectionally, but none of the adipokines can serve as surrogates for the fat depots. Relations between VAT, SAT, and cardiometabolic risk factors were not fully explained by adiponectin or resistin concentrations.
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影响因子：
5.8
作者：
Araki, Shunsuke;Dobashi, Kazushige;Shirahata, Akira
通讯作者：
Shirahata, Akira
影响因子：
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作者：
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作者：
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通讯作者：
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影响因子：
16.2
作者：
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通讯作者：
Cummings, SR
影响因子：
2.2
作者：
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