Clinical high risk and first episode schizophrenia: auditory event-related potentials.
Clinical high risk and first episode schizophrenia: auditory event-related potentials.
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DOI：
10.1016/j.pscychresns.2014.11.012
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发表时间：
2015-02-28
影响因子：
11.3
通讯作者：
Niznikiewicz MA
中科院分区：
文献类型：
--
作者：
del Re EC;Spencer KM;Oribe N;Mesholam-Gately RI;Goldstein J;Shenton ME;Petryshen T;Seidman LJ;McCarley RW;Niznikiewicz MA
临床高危期（CHR）是指有明显精神病风险的阶段，在此期间经常出现亚急性症状，认知功能可能恶化。为了比较这一阶段的生物学指标与首发精神分裂症的生物学指标，我们横断面检查了性别和年龄匹配的临床高危人群（CHR, n=21）、首发精神分裂症患者（FESZ, n=20）和匹配的健康对照（HC, n=25）的古怪范式和新颖性范式，并评估了N100、P200、P3a和P3b作为知觉、注意和工作记忆过程的指标。据我们所知，这是在两种范式中使用所有这些事件相关电位（erp）的唯一比较。我们假设，erp将区分三组，并允许诊断组的预测。与对照组相比，CHR和FESZ组的大多数erp受到显著影响，效应大小相似。然而，在逻辑回归中，只有P3a和N100将CHR和FESZ与健康对照区分开来，这表明与显性任务无关的erp可能对群体成员的预测更敏感。
The clinical high risk (CHR) period is a phase denoting a risk for overt psychosis during which subacute symptoms often appear, and cognitive functions may deteriorate. To compare biological indices during this phase with those during first episode schizophrenia, we cross-sectionally examined sex- and age-matched clinical high risk (CHR, n=21), first episode schizophrenia patients (FESZ, n=20) and matched healthy controls (HC, n=25) on oddball and novelty paradigms and assessed the N100, P200, P3a and P3b as indices of perceptual, attentional and working memory processes. To our knowledge, this is the only such comparison using all of these event-related potentials (ERPs) in two paradigms. We hypothesized that the ERPs would differentiate between the three groups and allow prediction of a diagnostic group. The majority of ERPs were significantly affected in CHR and FESZ compared with controls, with similar effect sizes. Nonetheless, in logistic regression, only the P3a and N100 distinguished CHR and FESZ from healthy controls, suggesting that ERPs not associated with an overt task might be more sensitive to prediction of group membership.
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影响因子：
6.8
作者：
Del Re EC;Bergen SE;Mesholam-Gately RI;Niznikiewicz MA;Goldstein JM;Woo TU;Shenton ME;Seidman LJ;McCarley RW;Petryshen TL
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