Microstructural but not macrostructural cortical degeneration occurs in Parkinson's disease with mild cognitive impairment.
Microstructural but not macrostructural cortical degeneration occurs in Parkinson's disease with mild cognitive impairment.
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DOI：
10.1038/s41531-022-00416-6
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发表时间：
2022-11-09
影响因子：
8.7
通讯作者：
Zhang, Minming
中科院分区：
文献类型：
--
作者：
Bai, Xueqin;Guo, Tao;Chen, Jingwen;Guan, Xiaojun;Zhou, Cheng;Wu, Jingjing;Liu, Xiaocao;Wu, Haoting;Wen, Jiaqi;Gu, Luyan;Gao, Ting;Xuan, Min;Huang, Peiyu;Zhang, Baorong;Xu, Xiaojun;Zhang, Minming
本研究旨在探讨帕金森病(PD)伴轻度认知障碍(MCI)患者大脑皮质微结构/宏观结构的退行性改变模式。总体而言，38名认知正常的帕金森病患者(PD-NC)、38名PD-MCI患者和32名健康对照组(HC)纳入研究。根据MDS工作组II级标准诊断PD-MCI。用轴突定向、弥散和密度成像评价皮质微结构的改变。皮质厚度分析来自使用Freesurfer软件的T1加权成像。在皮质显微结构分析中，与HC相比，PD-NC在双侧扣带回和扣带旁回、辅助运动区、右侧中央旁小叶和楔前脑区的定向离散指数较低(PFWE <； )，而PD-MCI在双侧额、顶叶、枕叶和右侧颞区的广泛区域显示较低的定向离散指数，在左额叶、左侧扣带回和扣带旁回显示较低的轴突密度指数(PFWE <； 0.05)。此外，与PD-NC相比，PD-MCI患者右侧额叶和双侧尾状核(体素P <； )的ODI值降低，且其ODI值与蒙特利尔认知评估评分(r = 0.440，P <； 0.001)和记忆成绩(r = 0.333，P = 0.004)相关。然而，对于皮质厚度分析，在组间比较中没有差异。总之，在PD-MCI中，皮质微结构的改变可能先于宏观结构的改变。本研究为PD-MCI的退变模式提供了有洞察力的证据，有助于我们理解帕金森病早期认知损害的皮质神经突起变化的潜在生物学基础。
This study aimed to investigate the cortical microstructural/macrostructural degenerative patterns in Parkinson’s disease (PD) patients with mild cognitive impairment (MCI). Overall, 38 PD patients with normal cognition (PD-NC), 38 PD-MCI, and 32 healthy controls (HC) were included. PD-MCI was diagnosed according to the MDS Task Force level II criteria. Cortical microstructural alterations were evaluated with Neurite Orientation Dispersion and Density Imaging. Cortical thickness analyses were derived from T1-weighted imaging using the FreeSurfer software. For cortical microstructural analyses, compared with HC, PD-NC showed lower orientation dispersion index (ODI) in bilateral cingulate and paracingulate gyri, supplementary motor area, right paracentral lobule, and precuneus (PFWE < 0.05); while PD-MCI showed lower ODI in widespread regions covering bilateral frontal, parietal, occipital, and right temporal areas and lower neurite density index in left frontal area, left cingulate, and paracingulate gyri (PFWE < 0.05). Furthermore, compared with PD-NC, PD-MCI showed reduced ODI in right frontal area and bilateral caudate nuclei (voxel P < 0.01 and cluster >100 voxels) and the ODI values were associated with the Montreal Cognitive Assessment scores (r = 0.440, P < 0.001) and the memory performance (r = 0.333, P = 0.004) in the PD patients. However, for cortical thickness analyses, there was no difference in the between-group comparisons. In conclusion, cortical microstructural alterations may precede macrostructural changes in PD-MCI. This study provides insightful evidence for the degenerative patterns in PD-MCI and contributes to our understanding of the latent biological basis of cortical neurite changes for early cognitive impairment in PD.
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影响因子：
2.9
作者：
Huang P;Shen Z;Wang C;Qian W;Zhang H;Yang Y;Zhang M
通讯作者：
Zhang M
影响因子：
11
作者：
HUGHES, AJ;DANIEL, SE;LEES, AJ
通讯作者：
LEES, AJ
影响因子：
25
作者：
Guo L;Xiong H;Kim JI;Wu YW;Lalchandani RR;Cui Y;Shu Y;Xu T;Ding JB
通讯作者：
Ding JB
影响因子：
11.1
作者：
Blumenstock S;Rodrigues EF;Peters F;Blazquez-Llorca L;Schmidt F;Giese A;Herms J
通讯作者：
Herms J
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
通讯作者：
Sereno, MI