Bacterial profiles of saliva in relation to diet, lifestyle factors, and socioeconomic status.
Bacterial profiles of saliva in relation to diet, lifestyle factors, and socioeconomic status.
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DOI：
10.3402/jom.v6.23609
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发表时间：
2014
影响因子：
4.5
通讯作者：
Fiehn NE
中科院分区：
文献类型：
--
作者：
Belstrøm D;Holmstrup P;Nielsen CH;Kirkby N;Twetman S;Heitmann BL;Klepac-Ceraj V;Paster BJ;Fiehn NE
唾液的细菌图谱由来自不同口腔表面的细菌组成。这项研究的目的是确定不同的饮食摄入量、生活方式或社会经济状况是否与典型的细菌唾液特征有关。丹麦健康检查调查(DANHES)登记了292名患有低水平龋齿和牙周炎的参与者的刺激唾液样本，通过人类口腔微生物鉴定微阵列(HOMIM)分析了大约300种细菌的存在。以细菌探针的存在和水平(平均HOMIM值)为终点，采用Mann-Whitney检验和Benjamini-Hochberg的多重比较校正和主成分分析，分析饮食摄入量、生活方式和社会经济状况对细菌唾液谱的影响。在292个样本中鉴定了131种不同探针的靶标，其中链球菌和韦洛氏菌是最主要的鉴定属。两个细菌分类群(远缘链球菌和细小肠杆菌[11][G-3]短毛)与吸烟者的相关性比不吸烟者更高(调整后的p值和lt；0.01)。根据年龄、性别、饮酒量、体重指数(BMI)和饮食摄入量等参数对分组的分层对唾液细菌组成谱无统计学影响。相反，社会经济地位的差异反映在唾液的细菌图谱上。唾液的细菌图谱似乎与饮食摄入量无关，但受到吸烟的影响，可能还受社会经济地位的影响。
The bacterial profile of saliva is composed of bacteria from different oral surfaces. The objective of this study was to determine whether different diet intake, lifestyle, or socioeconomic status is associated with characteristic bacterial saliva profiles. Stimulated saliva samples from 292 participants with low levels of dental caries and periodontitis, enrolled in the Danish Health Examination Survey (DANHES), were analyzed for the presence of approximately 300 bacterial species by means of the Human Oral Microbe Identification Microarray (HOMIM). Using presence and levels (mean HOMIM-value) of bacterial probes as endpoints, the influence of diet intake, lifestyle, and socioeconomic status on the bacterial saliva profile was analyzed by Mann–Whitney tests with Benjamini–Hochberg's correction for multiple comparisons and principal component analysis. Targets for 131 different probes were identified in 292 samples, with Streptococcus and Veillonella being the most predominant genera identified. Two bacterial taxa (Streptococcus sobrinus and Eubacterium [11][G-3] brachy) were more associated with smokers than non-smokers (adjusted p-value<0.01). Stratification of the group based on extreme ends of the parameters age, gender, alcohol consumption, body mass index (BMI), and diet intake had no statistical influence on the composition of the bacterial profile of saliva. Conversely, differences in socioeconomic status were reflected by the bacterial profiles of saliva. The bacterial profile of saliva seems independent of diet intake, but influenced by smoking and maybe socioeconomic status.
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影响因子：
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作者：
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通讯作者：
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