Composition of the adult digestive tract bacterial microbiome based on seven mouth surfaces, tonsils, throat and stool samples.
Composition of the adult digestive tract bacterial microbiome based on seven mouth surfaces, tonsils, throat and stool samples.
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DOI：
10.1186/gb-2012-13-6-r42
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发表时间：
2012-06-14
期刊：
影响因子：
12.3
通讯作者：
Izard J
中科院分区：
文献类型：
--
作者：
Segata N;Haake SK;Mannon P;Lemon KP;Waldron L;Gevers D;Huttenhower C;Izard J
为了了解细菌微生物组与健康之间的关系，有必要在没有疾病的情况下定义微生物组。消化道包含多种栖息地，并且拥有人体最大的细菌密度。我们描述了参与人类微生物组计划的 200 多名正常成年人的 10 个消化道部位的细菌群落组成，并通过宏基因组确定了四个代表性部位的代谢潜力。这些不同栖息地的微生物群根据相似的群落组成形成了四组：颊粘膜、角化牙龈、硬腭；唾液、舌头、扁桃体、喉咙；龈下和龈上菌斑；和凳子。最初从环境样本中鉴定出的门在整个种群中均被检测到，主要是 TM7、SR1 和 Synergistetes。在这个无病队列中，具有致病成员的属有很好的代表性。牙齿相关群落与其他口腔表面不同，但并非完全不同。紫单胞菌科、韦永菌科和毛螺菌科在所有地点都很常见，但它们属的分布差异很大。大多数代谢过程广泛分布在整个消化道微生物群中，不同身体栖息地之间的宏基因组丰度存在差异。其中包括龈上菌斑、其他口腔表面和粪便之间糖转运蛋白类型的变化；氢气和硫化氢的产量分布也存在差异。十个消化道部位的微生物组根据组成分为四种类型。这些不同的消化道栖息地中存在一组核心代谢途径。这些数据为未来研究影响人类健康的局部和全身疾病提供了重要的基线。
To understand the relationship between our bacterial microbiome and health, it is essential to define the microbiome in the absence of disease. The digestive tract includes diverse habitats and hosts the human body's greatest bacterial density. We describe the bacterial community composition of ten digestive tract sites from more than 200 normal adults enrolled in the Human Microbiome Project, and metagenomically determined metabolic potentials of four representative sites. The microbiota of these diverse habitats formed four groups based on similar community compositions: buccal mucosa, keratinized gingiva, hard palate; saliva, tongue, tonsils, throat; sub- and supra-gingival plaques; and stool. Phyla initially identified from environmental samples were detected throughout this population, primarily TM7, SR1, and Synergistetes. Genera with pathogenic members were well-represented among this disease-free cohort. Tooth-associated communities were distinct, but not entirely dissimilar, from other oral surfaces. The Porphyromonadaceae, Veillonellaceae and Lachnospiraceae families were common to all sites, but the distributions of their genera varied significantly. Most metabolic processes were distributed widely throughout the digestive tract microbiota, with variations in metagenomic abundance between body habitats. These included shifts in sugar transporter types between the supragingival plaque, other oral surfaces, and stool; hydrogen and hydrogen sulfide production were also differentially distributed. The microbiomes of ten digestive tract sites separated into four types based on composition. A core set of metabolic pathways was present across these diverse digestive tract habitats. These data provide a critical baseline for future studies investigating local and systemic diseases affecting human health.
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影响因子：
9.3
作者：
Al-Attas OS;Al-Daghri NM;Al-Rubeaan K;da Silva NF;Sabico SL;Kumar S;McTernan PG;Harte AL
通讯作者：
Harte AL
影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
7.6
作者：
Barnes, V. M.;Teles, R.;Guo, L.
通讯作者：
Guo, L.
DOI：
10.1038/ismej.2010.30
发表时间：
2010-08
期刊：
The ISME journal
影响因子：
--
作者：
通讯作者：
--
影响因子：
3.7
作者：
Andersson, Anders F.;Lindberg, Mathilda;Jakobsson, Hedvig;Backhed, Fredrik;Nyren, Pal;Engstrand, Lars
通讯作者：
Engstrand, Lars