Molecular characteristics and risk factor analysis of Staphylococcus aureus colonization put insight into CC1 colonization in three nursing homes in Shanghai.
Molecular characteristics and risk factor analysis of Staphylococcus aureus colonization put insight into CC1 colonization in three nursing homes in Shanghai.
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金黄色葡萄球菌定植的分子特征和危险因素分析有助于深入了解上海三所养老院的 CC1 定植情况
DOI：
10.1371/journal.pone.0253858
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Han LZ
中科院分区：
文献类型：
--
作者：
He WP;Gu FF;Zhang J;Li XX;Xiao SZ;Zeng Q;Ni YX;Han LZ
研究表明，具有易感风险的老年人体内金黄色葡萄球菌的定植与随后的感染有关。然而，中国疗养院（NH）居民和工作人员中金黄色葡萄球菌定植的分子流行病学和危险因素仍不清楚。 2019 年 9 月至 2019 年 10 月期间，在上海的三个卫生机构进行了一项多中心研究。我们探讨了金黄色葡萄球菌定植的患病率、分子流行病学和危险因素。所有金黄色葡萄球菌分离株均根据抗菌素耐药性、毒力基因、多位点序列分型 (MLST)、葡萄球菌蛋白 A (spa) 分型和葡萄球菌盒式染色体 mec (SCCmec) 分型进行表征。检查 NH 记录中金黄色葡萄球菌定植的潜在危险因素。在接受筛查的 496 名居民和 55 名工作人员中，分别在 109 名（100 名居民和 9 名工作人员，19.8%，109/551）和 28 名（24 名居民和 4 名工作人员，5.1%，28/551）受试者中检测到金黄色葡萄球菌和耐甲氧西林金黄色葡萄球菌（MRSA）分离株。与甲氧西林敏感金黄色葡萄球菌分离株相比，所有30株MRSA分离株对除米诺环素、利福平、利奈唑胺、万古霉素和替考拉宁之外的大多数抗生素均具有较高的耐药率。在 122 株金黄色葡萄球菌分离株中，序列类型 (ST) 1 (21.3%) 是最常见的序列类型，t127 (20.5%) 是最常见的 spa 类型。 SCCmec I 型 (70%) 是所有 MRSA 分离株中的优势克隆。 CC1 (26/122, 21.3%) 是主要的复合克隆 (CC)，其次是 CC398 (25/122, 20.5%)、CC5 (20/122, 16.4%) 和 CC188 (18/122, 14.8%)。女性（OR，1.70；95% CI，1.04-2.79；P = 0.036）和侵入性装置（OR，2.19；95% CI，1.26-3.81；P = 0.006）与金黄色葡萄球菌定植独立相关。
Research indicates that Staphylococcus aureus colonization in the elderly with predisposing risks is associated with subsequent infection. However, the molecular epidemiology and risk factors for S. aureus colonization among residents and staff in nursing homes (NHs) in China remain unclear. A multicenter study was conducted in three NHs in Shanghai between September 2019 and October 2019. We explored the prevalence, molecular epidemiology, and risk factors for S. aureus colonization. All S. aureus isolates were characterized based on antimicrobial resistance, virulence genes, multilocus sequence typing (MLST), staphylococcus protein A (spa) typing, and staphylococcal cassette chromosome mec (SCCmec) typing. NH records were examined for potential risk factors for S. aureus colonization. S. aureus and methicillin-resistant S. aureus (MRSA) isolates were detected in 109 (100 residents and 9 staff, 19.8%, 109/551) and 28 (24 residents and 4 staff, 5.1%, 28/551) subjects among 496 residents and 55 staff screened, respectively. Compared to methicillin-susceptible S. aureus isolates, all 30 MRSA isolates had higher resistance rates to most antibiotics except minocycline, rifampicin, linezolid, vancomycin, and teicoplanin. Sequence type (ST) 1 (21.3%) was the most common sequence type, and t127 (20.5%) was the most common spa type among 122 S. aureus isolates. SCCmec type I (70%) was the dominant clone among all MRSA isolates. CC1 (26/122, 21.3%) was the predominant complex clone (CC), followed by CC398 (25/122, 20.5%), CC5 (20/122, 16.4%) and CC188 (18/122, 14.8%). Female sex (OR, 1.70; 95% CI, 1.04–2.79; P = 0.036) and invasive devices (OR, 2.19; 95% CI, 1.26–3.81; P = 0.006) were independently associated with S. aureus colonization.
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影响因子：
3.7
作者：
De Jong, Nienke W. M.;Van Kessel, Kok P. M.;Van Strijp, Jos A. G.
通讯作者：
Van Strijp, Jos A. G.
上海外地皮肤软组织感染患者金黄色葡萄球菌特征分析
影响因子：
3.7
作者：
Gu FF;Hou Q;Yang HH;Zhu YQ;Guo XK;Ni YX;Han LZ
通讯作者：
Han LZ
影响因子：
3.1
作者：
Dumyati G;Stone ND;Nace DA;Crnich CJ;Jump RL
通讯作者：
Jump RL
DOI：
10.1007/s10096-019-03523-0
发表时间：
2019-05-01
影响因子：
4.5
作者：
Deasy, Emily C.;Brennan, Grainne L.;Shore, Anna C.
通讯作者：
Shore, Anna C.
影响因子：
9.4
作者：
Cha, HY;Moon, DC;Lee, JC
通讯作者：
Lee, JC