Cortical substrates of cue-reactivity in multiple substance dependent populations: transdiagnostic relevance of the medial prefrontal cortex.
Cortical substrates of cue-reactivity in multiple substance dependent populations: transdiagnostic relevance of the medial prefrontal cortex.
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多种物质依赖人群中线索反应性的皮质底物：内侧前额叶皮质的跨诊断相关性。
DOI：
10.1038/s41398-018-0220-9
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发表时间：
2018-09-07
影响因子：
6.8
通讯作者：
Hoffman M
中科院分区：
文献类型：
--
作者：
Hanlon CA;Dowdle LT;Gibson NB;Li X;Hamilton S;Canterberry M;Hoffman M
升高的药物线索引起的大脑活动是物质依赖人群中最广泛引用的转诊断相关特征之一。然而，这些人群通常被孤立地研究。本研究的目的是前瞻性地调查空间地形的药物线索反应性在一个大的个人依赖于可卡因，酒精，或尼古丁。从156名物质依赖者（55名可卡因，53名酒精和48名尼古丁）获得功能性MRI数据，因为他们执行了标准化的药物线索暴露任务。集群的显着激活药物线索相对于中性线索（“热点”）被隔离为每个人。利用K-均值聚类对数据集中热点区域的空间拓扑进行分类。计算在经颅磁刺激（TMS）的几个距离（2- 5cm）处将到达的热点的百分比。103名参与者至少有一组显著的额叶皮层活动（66%）。K-means显示内侧前额叶皮层（MPFC）、左侧额下回/额下回、右侧运动前皮层内有3个不同的簇。对于整个群体（以及酒精使用者和尼古丁使用者），内侧前额叶皮层（BA 10）是最多热点的位置。额极是最接近热点百分比最大的皮层位置。虽然存在个体差异的线索引起的“热点”的位置，这些数据表明，在MPFC中的药物线索的BOLD信号升高可能是一个transdiagnosis的内表型成瘾，这也可能是一个富有成效的神经调节目标。
Elevated drug-cue elicited brain activity is one of the most widely cited, transdiagnostically relevant traits of substance dependent populations. These populations, however, are typically studied in isolation. The goal of this study was to prospectively investigate the spatial topography of drug-cue reactivity in a large set of individuals dependent on either cocaine, alcohol, or nicotine. Functional MRI data was acquired from 156 substance dependent individuals (55 cocaine, 53 alcohol, and 48 nicotine) as they performed a standardized drug-cue exposure task. Clusters of significant activation to drug-cues relative to neutral cues (‘hot spots’) were isolated for each individual. K-means clustering was used to classify the spatial topography of the hotspots in the data set. The percentage of hotspots that would be reached at several distances (2–5 cm) of transcranial magnetic stimulation (TMS) were calculated. One hundred and three participants had at least one cluster of significant frontal cortex activity (66%). K-means revealed 3 distinct clusters within the medial prefrontal cortex (MPFC), left inferior frontal gyrus/insula, right premotor cortex. For the group as a whole (and for alcohol users and nicotine users independently), medial prefrontal cortex (BA 10) was the location of the greatest number of hotspots. The frontal pole was cortical location closest to the largest percentage of hotspots. While there is individual variability in the location of the cue-elicited ‘hot spot’ these data demonstrate that elevated BOLD signal to drug cues in the MPFC may be a transdiagnostic endophenotype of addiction which may also be a fruitful neuromodulation target.
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影响因子：
4.2
作者：
Hanlon, Colleen A.;Dowdle, Logan T.;Naselaris, Thomas;Canterberry, Melanie;Cortese, Bernadette M.
通讯作者：
Cortese, Bernadette M.
影响因子：
7.6
作者：
McClernon, FJ;Hiott, FB;Rose, JE
通讯作者：
Rose, JE
影响因子：
--
作者：
Myrick, Hugh;Anton, Rayinond F.;Voronin, Konstantin
通讯作者：
Voronin, Konstantin
影响因子：
6
作者：
O'Connell, Kathleen A.;Shiffman, Saul;DeCarlo, Lawrence T.
通讯作者：
DeCarlo, Lawrence T.
影响因子：
3.4
作者：
Courtney KE;Schacht JP;Hutchison K;Roche DJ;Ray LA
通讯作者：
Ray LA