miRMaid: a unified programming interface for microRNA data resources.
miRMaid: a unified programming interface for microRNA data resources.
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DOI：
10.1186/1471-2105-11-29
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发表时间：
2010-01-14
影响因子：
3
通讯作者：
Lindow M
中科院分区：
文献类型：
--
作者：
Jacobsen A;Krogh A;Kauppinen S;Lindow M
微小RNA（microRNAs，miRNAs）是一类内源性小分子RNA，在动植物基因表达的转录后调控中发挥重要作用。近年来，已知的miRNAs数量迅速增加。目前发布的miRBase（版本14.0）是miRNA注释的中央在线存储库，包含来自115个不同物种的超过10.000种miRNA前体。此外，现在有大量分散的在线资源，每个都提供重要的miRNA注释和信息。我们已经开发了一个软件框架，在这里指定为miRMaid，与统一的Web服务接口，可以访问和查询的研究人员，最重要的是，通过计算机的目标是整合miRNA数据资源。miRMaid基于miRBase数据构建，旨在遵循miRBase官方数据发布。它将miRBase数据公开为互连的Web服务。第三方miRNA数据资源可以模块化集成为miRMaid插件，或者它们可以与miRMaid松散耦合为万维网中的个体实体。miRMaid作为公共Web服务提供，但也可以作为本地应用程序轻松安装。该软件框架在LGPL开源许可下免费提供，用于学术和商业用途。miRMaid是一个直观的模块化软件平台，旨在统一miRBase和独立的miRNA数据资源。它使miRNA研究人员能够通过计算解决涉及大量miRNA数据资源的复杂问题。此外，miRMaid构成了进一步编程的基本框架，其中对microRNA感兴趣的生物信息学家可以很容易地开发自己的工具和数据源。
MicroRNAs (miRNAs) are endogenous small RNAs that play a key role in post-transcriptional regulation of gene expression in animals and plants. The number of known miRNAs has increased rapidly over the years. The current release (version 14.0) of miRBase, the central online repository for miRNA annotation, comprises over 10.000 miRNA precursors from 115 different species. Furthermore, a large number of decentralized online resources are now available, each contributing with important miRNA annotation and information. We have developed a software framework, designated here as miRMaid, with the goal of integrating miRNA data resources in a uniform web service interface that can be accessed and queried by researchers and, most importantly, by computers. miRMaid is built around data from miRBase and is designed to follow the official miRBase data releases. It exposes miRBase data as inter-connected web services. Third-party miRNA data resources can be modularly integrated as miRMaid plugins or they can loosely couple with miRMaid as individual entities in the World Wide Web. miRMaid is available as a public web service but is also easily installed as a local application. The software framework is freely available under the LGPL open source license for academic and commercial use. miRMaid is an intuitive and modular software platform designed to unify miRBase and independent miRNA data resources. It enables miRNA researchers to computationally address complex questions involving the multitude of miRNA data resources. Furthermore, miRMaid constitutes a basic framework for further programming in which microRNA-interested bioinformaticians can readily develop their own tools and data sources.
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影响因子：
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作者：
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通讯作者：
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影响因子：
14.9
作者：
Griffiths-Jones, Sam;Saini, Harpreet Kaur;van Dongen, Stijn;Enright, Anton J.
通讯作者：
Enright, Anton J.