Children with amblyaudia show less flexibility in auditory cortical entrainment to periodic non-speech sounds.

Children with amblyaudia show less flexibility in auditory cortical entrainment to periodic non-speech sounds.
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DOI:
10.1080/14992027.2022.2094289
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发表时间:
2023-10
影响因子:
2.7
通讯作者:
--
中科院分区:
医学3区
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我们通过皮质神经夹带研究了患有弱听症(AMB)(听觉处理障碍(APD)的一种亚型)的儿童的听觉时间处理。在 n = 14 名患有 AMB 的儿童和 n = 11 名年龄匹配的对照组中,以慢速与快速(8.5 vs. 14.9/s)速率记录点击训练的诱发反应。源和时频分析(TFA)将脑电图分解为源自双侧听觉皮层的振荡(反映神经夹带)。 AMB 的锁相强度主要取决于听觉刺激的速度。与年龄匹配的同龄人相比,AMB 的反应对利率操纵基本上不敏感。无论是哪只耳朵以及两个皮质半球,都会出现这种速率阻力。患有 AMB 的儿童在听觉皮层夹带方面表现出较少的与速率相关的变化。除了耳朵之间整合信息的能力降低之外,我们还发现了对外部听觉刺激的更严格的标记。我们的神经生理学发现可以解释 AMB 和相关 APD 行为中常见的领域一般时间处理缺陷。更广泛地说,我们的研究结果可能会为沟通策略和未来的康复计划提供信息;将刺激速率提高到高于正常(慢)语速可能会使 AMB/APD 患者的刺激处理更具挑战性。
We investigated auditory temporal processing in children with amblyaudia (AMB), a subtype of auditory processing disorder (APD), via cortical neural entrainment. Evoked responses were recorded to click-trains at slow vs. fast (8.5 vs. 14.9/s) rates in n = 14 children with AMB and n = 11 age-matched controls. Source and time–frequency analyses (TFA) decomposed EEGs into oscillations (reflecting neural entrainment) stemming from bilateral auditory cortex. Phase-locking strength in AMB depended critically on the speed of auditory stimuli. In contrast to age-matched peers, AMB responses were largely insensitive to rate manipulations. This rate resistance occurred regardless of the ear of presentation and in both cortical hemispheres. Children with AMB show less rate-related changes in auditory cortical entrainment. In addition to reduced capacity to integrate information between the ears, we identify more rigid tagging of external auditory stimuli. Our neurophysiological findings may account for domain-general temporal processing deficits commonly observed in AMB and related APDs behaviourally. More broadly, our findings may inform communication strategies and future rehabilitation programmes; increasing the rate of stimuli above a normal (slow) speech rate is likely to make stimulus processing more challenging for individuals with AMB/APD.
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