Small nuclei identification with a hemispherical brain PET.
Small nuclei identification with a hemispherical brain PET.
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DOI：
10.1186/s40658-022-00498-4
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发表时间：
2022-10-08
期刊：
影响因子：
4
通讯作者：
Yamaya T
中科院分区：
文献类型：
--
作者：
Takahashi M;Akamatsu G;Iwao Y;Tashima H;Yoshida E;Yamaya T
为了证实我们开发的第一个用于大脑的半球正电子发射断层扫描(Vrain)的性能，我们将18F-脱氧葡萄糖(FDG)脑图像与全身PET图像进行了比较。10名健康男性志愿者(年龄22-45岁)接受了具有代表性的临床全身PET，然后每人进行10分钟的Vrain。这两次扫描分别在注射FDG(4.1 ± 0.5MBq/kg)后30min和45min开始。首先，我们从视觉上识别了小核团，然后将它们的标准化摄取值(SUV)与参与者的年龄进行了比较。接下来，通过对解剖归一化的PET图像应用感兴趣体积模板来确定每个大脑区域的SUV，在使用Vrain的大脑图像和使用全身PET图像的大脑图像之间进行比较。小核团，如下丘、红核和黑质，在Vrain中显示得比全身PET更清晰。丘脑的前核、背内侧核和脑干的中缝核在Vrain中可见，而在全身PET中未见。小脑下丘和齿状回的SUV与年龄呈正相关(Spearman相关系数r = 为0.811，p = 为0.004；r = 为0.738，p = 为0.015)。Vrain在内侧顶叶和内侧颞叶的SUV略高于全身PET。这是第一次使用第一半球脑PET成功地显示中缝核、前核团和背内侧核团。日本临床试验注册，JRCTs032210086，注册于2021年5月13日，https://jrct.niph.go.jp/latest-detail/jRCTs032210086.
To confirm the performance of the first hemispherical positron emission tomography (PET) for the brain (Vrain) that we developed to visualise the small nuclei in the deep brain area, we compared 18F-fluorodeoxyglucose (FDG) brain images with whole-body PET images. Ten healthy male volunteers (aged 22–45 years) underwent a representative clinical whole-body PET, followed by Vrain each for 10 min. These two scans were initiated 30 min and 45 min after FDG injection (4.1 ± 0.5 MBq/kg), respectively. First, we visually identified the small nuclei and then compared their standardised uptake values (SUVs) with the participants’ age. Next, the SUVs of each brain region, which were determined by applying a volume-of-interest template for anatomically normalised PET images, were compared between the brain images with the Vrain and those with the whole-body PET images. Small nuclei, such as the inferior colliculus, red nucleus, and substantia nigra, were more clearly visualised in Vrain than in whole-body PET. The anterior nucleus and dorsomedial nucleus in the thalamus and raphe nucleus in the brainstem were identified in Vrain but not in whole-body PET. The SUVs of the inferior colliculus and dentate gyrus in the cerebellum positively correlated with age (Spearman’s correlation coefficient r = 0.811, p = 0.004; r = 0.738, p = 0.015, respectively). The SUVs of Vrain were slightly higher in the mesial temporal and medial parietal lobes than those in whole-body PET. This was the first time that the raphe nuclei, anterior nuclei, and dorsomedial nuclei were successfully visualised using the first hemispherical brain PET. Japan Registry of Clinical Trials, jRCTs032210086, Registered 13 May 2021, https://jrct.niph.go.jp/latest-detail/jRCTs032210086.
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