Early postnatal noise exposure degrades the stimulus-specific adaptation of neurons in the rat auditory cortex in adulthood
Early postnatal noise exposure degrades the stimulus-specific adaptation of neurons in the rat auditory cortex in adulthood
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出生后早期噪声暴露会降低成年大鼠听觉皮层神经元的刺激特异性适应能力
DOI：
10.1016/j.neuroscience.2019.01.064
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发表时间：
2019-04
期刊：
影响因子：
3.3
通讯作者：
Zhang Jiping
中科院分区：
文献类型：
--
作者：
Wang Fang;Liu Jing;Zhang Jiping
许多听觉皮质神经元表现出刺激特异性适应(SSA)，即它们对频繁出现的刺激反应弱，但对相同的刺激很少出现时反应强烈。SSA已被建议作为一种潜在的机制来进行异常检测或新奇检测。以往对SSA的研究是在正常环境下饲养的动物身上进行的。已有研究表明，出生后早期噪声暴露会损害大脑皮质对声音信息的处理能力。然而，目前尚不清楚出生后中等水平噪声暴露是否会影响初级听觉皮质(AI)的SSA，如果是，噪声暴露对SSA的影响是否会随着噪声暴露时间的不同而不同。在此，我们使用频率奇异法测定了三组大鼠的AI神经元的SSA：对照组大鼠在没有噪声暴露的正常环境中饲养，青年噪声暴露组大鼠从P10到P56接受70dBSPL白噪声暴露，成年噪声暴露大鼠从P57到P103接受相同的噪声暴露。我们发现，出生后早期的噪声暴露降低了幼年噪声暴露大鼠AI中SSA神经元的比例，并降低了成年大鼠AI神经元的SSA强度。相比之下，成年大鼠同样的噪声暴露对成年噪声暴露大鼠AI神经元的SSA没有显著影响。结果提示，环境噪声可能是声音序列中频率偏离的皮质加工在出生后异常发育的危险因素。
Many auditory cortical neurons exhibit stimulus-specific adaptation (SSA), i.e., they respond weakly to frequently occurring stimuli but strongly to the same stimuli when presented rarely. SSA has been proposed to be a potential mechanism to engage deviance detection or novelty detection. Previous studies on SSA were investigated in animals reared in normal environment. It has been shown that early postnatal noise exposure impairs the development of cortical processing of sound information. However, it is not understood whether postnatal middle-level noise exposure affects the SSA in the primary auditory cortex (AI), and if yes, whether the impacts of noise exposure on SSA varied with noise exposure periods. Here we used a frequency oddball paradigm to determine the SSA of AI neurons in three groups of rats: the control rats were reared in normal environment without noise exposure, the young noise-exposed rats received a 70 dB SPL white noise exposure from P10 to P56, and the adult noise-exposed rats received the same noise exposure from P57 to P103. We found that early postnatal noise exposure reduced the proportion of SSA neurons in AI and decreased the strength of SSA of AI neurons in the young noise-exposed rats in adulthood. In contrast, the same noise exposure to adult rats had no significant impacts on the SSA of AI neurons in adult noise-exposed rats. The results suggest that environmental noise might be a risk factor for abnormal postnatal development of cortical processing of frequency deviance in a sound sequence.
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影响因子：
2.9
作者：
D. Šuta;N. Rybalko;D-W Shen;J. Popelář;P. Poon;J. Syka
通讯作者：
D. Šuta;N. Rybalko;D-W Shen;J. Popelář;P. Poon;J. Syka
影响因子：
4.7
作者：
Jacobsen, T;Schröger, E
通讯作者：
Schröger, E
影响因子：
16.6
作者：
Xiaoming Zhou;M. Merzenich
通讯作者：
Xiaoming Zhou;M. Merzenich
影响因子：
3.4
作者：
Anderson, L. A.;Malmierca, M. S.
通讯作者：
Malmierca, M. S.
环境丰富可以挽救早期噪声暴露引起的皮质神经元听觉时间分辨率下降
影响因子：
3.4
作者：
Jiang, Cuiping;Xu, Xiaoxiao;Zhang, Jiping
通讯作者：
Zhang, Jiping