Myelination of the corpus callosum in male and female rats following complex environment housing during adulthood.
Myelination of the corpus callosum in male and female rats following complex environment housing during adulthood.
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DOI：
10.1016/j.brainres.2009.06.087
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发表时间：
2009-09-08
期刊：
影响因子：
2.9
通讯作者：
Greenough WT
中科院分区：
文献类型：
--
作者：
Markham JA;Herting MM;Luszpak AE;Juraska JM;Greenough WT
髓鞘形成是大脑发育的一个重要过程，这一过程的延迟或异常与许多疾病有关，包括自闭症、发育迟缓、注意力缺陷障碍和精神分裂症。髓鞘形成可能对发育经历敏感；然而，尽管成年大脑仍然具有高度可塑性，但髓鞘形成是否仍然对成年期间的经历敏感尚不清楚。雄性和雌性大鼠被社会饲养直到四个月大，此时它们被转移到复杂或“丰富”的环境（EC）或隔离条件（IC）中。虽然在 EC 饲养两个月后压部（胼胝体后部 20%，包含来自视觉皮层神经元的轴突）面积增加了约 10%，但有髓轴突占据的面积不受成人饲养条件的影响。相反，神经胶质细胞突起和无髓鞘轴突占据的区域在 EC 外壳后显着增加。膝部（胼胝体前部 15%）的大小和髓磷脂含量对成人居住条件的控制都不敏感，但雄性在两个胼胝体区域有更多的区域被有髓轴突占据。最后，使用定量电子显微镜在一组动物中证实了成年期间两个月的复杂环境住房无法影响压部中有髓轴突的数量。我们得出的结论是，相对于两性的发育，成年期髓鞘形成对经历的敏感性都会降低。
Myelination is an important process in brain development, and delays or abnormalities in this process have been associated with a number of conditions including autism, developmental delay, attention deficit disorder, and schizophrenia. Myelination can be sensitive to developmental experience; however, although the adult brain remains highly plastic, it is unknown whether myelination continues to be sensitive to experience during adulthood. Male and female rats were socially housed until four months of age, at which time they were moved into either a complex or “enriched” environment (EC) or an isolated condition (IC). Although the area of the splenium (posterior 20% of the callosum, which contains axons from visual cortical neurons) increased by about 10% following two months of EC housing, the area occupied by myelinated axons was not influenced by adult housing condition. Instead, it was the area occupied by glial cell processes and unmyelinated axons which significantly increased following EC housing. Neither the size nor the myelin content of the genu (anterior 15% of the callosum) was sensitive to manipulations of adult housing condition, but males had more area occupied by myelinated axons in both callosal regions. Finally, the inability of two months of complex environment housing during adulthood to impact the number of myelinated axons in the splenium was confirmed in a subset of animals using quantitative electron microscopy. We conclude that the sensitivity of myelination to experience is reduced in adulthood relative to development in both sexes.
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影响因子：
6.2
作者：
ANDERSON, BJ;LI, XC;GREENOUGH, WT
通讯作者：
GREENOUGH, WT
影响因子：
2.7
作者：
Jones, TA;Greenough, WT
通讯作者：
Greenough, WT
影响因子：
2.5
作者：
DIAMOND, MC;ROSENZWEIG, MR;KRECH, D
通讯作者：
KRECH, D
影响因子：
2.9
作者：
JURASKA, JM;KOPCIK, JR
通讯作者：
KOPCIK, JR
DOI：
10.1037/h0053731
发表时间：
1952-01-01
期刊：
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
FORGAYS, DG;FORGAYS, JW
通讯作者：
FORGAYS, JW