The aging lacrimal gland: changes in structure and function.
The aging lacrimal gland: changes in structure and function.
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DOI：
10.1016/s1542-0124(12)70177-5
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发表时间：
2008-10
期刊：
影响因子：
6.4
通讯作者：
Dartt, Darlene A.
中科院分区：
文献类型：
--
作者：
Rocha, Eduardo M.;Alves, Monica;Rios, J. David;Dartt, Darlene A.
角膜和结膜的传入神经、泪腺的传出神经和泪腺是协同工作产生泪液的水成分的功能单位。泪腺分泌功能下降会导致干眼症。由于衰老是干眼病的危险因素，因此研究泪腺功能单位的功能随年龄的变化对于开发预防干眼病的治疗方法非常重要。尽管有多种不同的机制与衰老相关，但目前还没有一种机制可以诱发衰老过程中发生的变化。这些理论分为两大类：衰老的程序化理论（免疫学、遗传、细胞凋亡和神经内分泌）和衰老的错误理论（蛋白质改变、体细胞突变等）。随着年龄的增长，泪腺的结构和功能会发生变化。在小鼠衰老模型中，研究表明蛋白质分泌的神经刺激是衰老的早期目标，伴随着肥大细胞的增加和脂褐素的积累。高血糖和淋巴细胞浸润增加可能导致老年功能丧失。这些发现表明，随着年龄的增长，氧化应激的增加可能在泪腺功能丧失中发挥作用。对于泪腺功能单位的传入和传出神经成分，免疫或炎症介导的神经功能下降可能导致泪腺分泌随着年龄的增长而丧失。迫切需要在这一领域进行更多研究。
The afferent nerves of the cornea and conjunctiva, efferent nerves of the lacrimal gland, and the lacrimal gland are a functional unit that works cooperatively to produce the aqueous component of tears. A decrease in the lacrimal gland secretory function can lead to dry eye disease. Because aging is a risk factor for dry eye disease, study of the changes in the function of the lacrimal gland functional unit with age is important for developing treatments to prevent dry eye disease. No one mechanism is known to induce the changes that occur with aging, although multiple different mechanisms have been associated with aging. These fall into two theoretical categories: programmed theories of aging (immunological, genetic, apoptotic, and neuroendocrine) and error theories of aging (protein alteration, somatic mutation, etc). Lacrimal glands undergo structural and functional alteration with increasing age. In mouse models of aging, it has been shown that neural stimulation of protein secretion is an early target of aging, accompanied by an increase in mast cells and lipofuscin accumulation. Hyperglycemia and increased lymphocytic infiltration can contribute to this loss of function at older ages. These findings suggest that an increase in oxidative stress may play a role in the loss of lacrimal gland function with age. For the afferent and efferent neural components of the lacrimal gland functional unit, immune or inflammatory mediated decrease in nerve function could contribute to loss of lacrimal gland secretion with age. More research in this area is critically needed.
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影响因子：
4.1
作者：
DAMATO, BE;ALLAN, D;LEE, WR
通讯作者：
LEE, WR
影响因子：
4.3
作者：
Garbe, James C.;Holst, Charles R.;Stampfer, Martha R.
通讯作者：
Stampfer, Martha R.
影响因子：
2.8
作者：
Erie, JC;McLaren, JW;Bourne, WM
通讯作者：
Bourne, WM
影响因子：
3.4
作者：
BROMBERG, BB;WELCH, MH
通讯作者：
WELCH, MH
影响因子：
--
作者：
DARTT, DA;DICKER, DM;MURPHY, SA
通讯作者：
MURPHY, SA