WeiTsing: a new face of Ca(2+)-permeable channels in plant immunity.
WeiTsing: a new face of Ca(2+)-permeable channels in plant immunity.
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DOI：
10.1007/s44154-023-00110-4
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发表时间：
2023-07-22
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--
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植物采用模式和效应触发免疫（PTI和ETI）协同防御入侵的病原体和昆虫食草动物。PTI和ETI都可以诱导胞浆Ca2+峰，尽管在不同的时空模式，激活下游Ca2+依赖性免疫信号级联。虽然质膜上的多个Ca2+渗透通道家族已经被发现，但负责从细胞内储存释放Ca2+的对应物仍然知之甚少。在Cell最近发表的一篇开创性论文中，作者报道了WeiQing，一种在Plasmodiophora brassicae（Pb）感染后特异性表达于周鞘中的拟南芥内质网（ER）驻留蛋白，可以形成抵抗体样Ca2+传导通道，保护芸苔属作物中柱免受Pb定殖。由于卫青的通道活性对于其免疫功能是不可或缺的，因此这些发现强调了以前未被充分认识的细胞内钙释放在促进植物抗病性中的作用。
Plants employ pattern- and effector-triggered immunity (PTI and ETI) to synergistically defend invading pathogens and insect herbivores. Both PTI and ETI can induce cytosolic Ca2+ spikes, despite in different spatiotemporal patterns, to activate downstream Ca2+-dependent immune signaling cascades. While multiple families of Ca2+-permeable channels at the plasma membrane have been uncovered, the counterparts responsible for Ca2+ release from intracellular stores remain poorly understood. In a groundbreaking paper published recently by Cell, the authors reported that WeiTsing, an Arabidopsis endoplasmic reticulum (ER)-resident protein that was specifically expressed in the pericycle upon Plasmodiophora brassicae (Pb) infection, could form resistosome-like Ca2+-conducting channel and protect the stele of Brassica crops from Pb colonization. As the channel activity of WeiTsing was indispensable for its immune function, the findings highlight a previously underappreciated role of Ca2+ release from intracellular repertoire in promoting plant disease resistance.
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