Prenatal exposure to perfluoroalkyl substances is associated with lower hand, foot and mouth disease viruses antibody response in infancy: Findings from the Guangzhou Birth Cohort Study.
Prenatal exposure to perfluoroalkyl substances is associated with lower hand, foot and mouth disease viruses antibody response in infancy: Findings from the Guangzhou Birth Cohort Study.
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产前接触全氟烷基物质与婴儿期手足口病病毒抗体反应较低有关：广州出生队列研究的结果。
DOI：
10.1016/j.scitotenv.2019.01.325
复制
发表时间：
2019-05
影响因子：
9.8
通讯作者：
Dong GH
中科院分区：
文献类型：
--
作者：
Zeng XW;Bloom M;Dharmage SC;Lodge CJ;Chen D;Li S;Guo Y;Roponen M;Jalava P;Hirvonen MR;Ma H;Hao YT;Chen W;Yang M;Chu C;Li QQ;Hu LW;Liu KK;Yang BY;Liu S;Fu C;Dong GH
背景全氟烷基化合物（PFASs）是广泛应用于工业和商业产品的合成化学品。它们的免疫调节作用是儿童日益关注的健康问题。手足口病（HFMD）是一种常见的儿童病毒感染，其发病率的增加与亚太地区PFAS暴露的增加平行。我们进行了第一项研究，以评估产前暴露于PFAS是否与婴儿HFMD病毒抗体的减少有关。采用高效液相色谱-质谱法测定脐带血中特定PFAS异构体的浓度。中和抗体滴度测定对两个手足口病病毒，肠道病毒71（EV 71）和柯萨奇病毒A 16（CA 16），在脐带血血清和血清在3个月龄。三个月大婴儿脐带血PFAS复合总和加倍与CA 16（比值比，OR：2.74 [95%置信区间（CI）：1.33，5.61]和EV 71（OR = 4.55，95% CI：1.45，4.28）的手足口病抗体浓度低于临床保护水平（滴度≥1：8）的风险显著增加相关。3个月龄时，男孩的CA 16水平更高。结论婴儿期接触脐带血PFAS与HFMD抗体水平降低有关。鉴于PFAS暴露的广泛性和全球手足口病的高发病率，这些发现具有重大的公共卫生意义，因此，需要在更大规模的研究中复制这些关联，以更明确地解决风险。
BackgroundPerfluoroalkyl substances (PFASs) are synthetic chemicals widely used in industry and for commercial products. Their immunomodulatory effects are a growing health concern in children. Hand, Foot and Mouth Disease (HFMD) is a common childhood viral infection, and increased incidence of which has parallel the rise in PFAS exposure in the Asia-Pacific region.ObjectiveWe conducted the first study to assess whether prenatal exposure to PFAS was associated with a reduction in HFMD virus antibodies in infants.MethodsWe enrolled 201 mother-infant pairs from the Guangzhou Birth Cohort Study from July to October 2013. High performance liquid chromatography-mass spectrometry was employed to determine concentrations of specific PFAS isomers in cord blood. Neutralizing antibodies titers were measured against two HFMD viruses, enterovirus 71 (EV71) and coxsackievirus A 16 (CA16), in cord blood serum and blood serum at three months of age.ResultsHigher umbilical cord blood PFAS concentrations were associated with lower EV71 and CA16 antibody concentrations. A doubling in the composite sum of cord blood PFASs in three month old infants was associated with significant increase in the risk of HFMD antibody concentration below clinical protection level (≥1:8 titers) for CA16 (odds ratio, OR: 2.74 [95% confidence interval (CI): 1.33, 5.61] and for EV71 (OR = 4.55, 95% CI: 1.45, 4.28). This association was higher in boys at three months of age for CA16.ConclusionsOur findings suggest that cord blood PFAS exposure is associated with lower HFMD antibody in infancy. Given the widespread nature of PFAS exposures and the high global incidence of HFMD globally, these findings have substantial public health implications and therefore, these associations need to be replicated in a larger study to more definitively address the risk.
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DOI：
10.1016/j.fct.2016.12.004
发表时间：
2017-03
期刊：
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
影响因子：
--
作者：
Rockwell CE;Turley AE;Cheng X;Fields PE;Klaassen CD
通讯作者：
Klaassen CD
影响因子：
5
作者：
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影响因子：
11.4
作者：
Gao, Yan;Fu, Jianjie;Jiang, Guibin
通讯作者：
Jiang, Guibin
影响因子：
3.3
作者：
Granum, Berit;Haug, Line S.;Nygaard, Unni C.
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DOI：
10.1073/pnas.1714765115
发表时间：
2018-01-16
影响因子：
11.1
作者：
Piasecka B;Duffy D;Urrutia A;Quach H;Patin E;Posseme C;Bergstedt J;Charbit B;Rouilly V;MacPherson CR;Hasan M;Albaud B;Gentien D;Fellay J;Albert ML;Quintana-Murci L;Milieu Intérieur Consortium
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Milieu Intérieur Consortium