Multimodal analysis of the hippocampus in schizophrenia using proton magnetic resonance spectroscopy and functional magnetic resonance imaging.
Multimodal analysis of the hippocampus in schizophrenia using proton magnetic resonance spectroscopy and functional magnetic resonance imaging.
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DOI：
10.1016/j.schres.2012.06.039
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发表时间：
2012-09
影响因子：
4.5
通讯作者：
Lahti AC
中科院分区：
文献类型：
--
作者：
Hutcheson NL;Reid MA;White DM;Kraguljac NV;Avsar KB;Bolding MS;Knowlton RC;den Hollander JA;Lahti AC
研究表明，精神分裂症患者患有记忆障碍。在这项研究中，我们结合质子磁共振波谱（1H-MRS）和功能磁共振成像（fMRI）来阐明精神分裂症记忆缺陷的神经生物学。我们使用在记忆任务执行期间在左海马体获得的单体素MRS和fMRI来获得28名稳定的精神分裂症患者（SZ）和28名匹配的健康对照（HC）的神经化学和功能反应的测量。SZ组在编码过程中左额下回（IFG）和检索过程中前扣带皮层（ACC）和颞上回（STG）的血氧水平依赖性（BOLD）信号显著降低。我们没有发现n -乙酰天冬氨酸/肌酸（NAA/Cr）或谷氨酸+谷氨酰胺（Glx/Cr）水平在两组之间存在显著差异，但HC组的NAA/Cr和Glx/Cr之间存在显著的正相关，而SZ组则不存在。在海马体中测量的BOLD和MRS之间没有显著的相关性。进一步分析显示，SZ组左IFG BOLD与任务表现呈负相关。最后，HC组左IFG BOLD与Glx/Cr呈正相关。我们重复了左侧IFG中BOLD信号减少的发现，以及SZ中IFG BOLD反应与任务表现之间关系的改变。患者NAA/Cr和Glx/Cr水平之间缺乏相关性可能提示谷氨酸-谷氨酰胺循环和/或线粒体的潜在病理。
Studies have shown that individuals with schizophrenia suffer from memory impairments. In this study, we combined proton magnetic resonance spectroscopy (1H-MRS) and functional magnetic resonance imaging (fMRI) to clarify the neurobiology of memory deficits in schizophrenia. We used single-voxel MRS acquired in the left hippocampus and fMRI during performance of a memory task to obtain measures of neurochemistry and functional response in 28 stable, medicated participants with schizophrenia (SZ) and 28 matched healthy controls (HC). The SZ group had significantly decreased blood oxygen level-dependent (BOLD) signal in left inferior frontal gyrus (IFG) during encoding and in the anterior cingulate cortex (ACC) and superior temporal gyrus (STG) during retrieval. We did not find significant differences in N-acetylaspartate/creatine (NAA/Cr) or glutamate + glutamine (Glx/Cr) levels between the groups, but did find a significant positive correlation between NAA/Cr and Glx/Cr in the HC group that was absent in the SZ group. There were no significant correlations between BOLD and MRS measured in the hippocampus. Further analyses revealed a negative correlation between left IFG BOLD and task performance in the SZ group. Finally, in the HC group, the left IFG BOLD was positively correlated with Glx/Cr. We replicated findings of reduced BOLD signal in left IFG and of an altered relationship between IFG BOLD response and task performance in the SZ. The absence of correlation between NAA/Cr and Glx/Cr levels in patients might suggest underlying pathologies of the glutamate-glutamine cycle and/or mitochondria.
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