Perceived stress is linked to heightened biomarkers of inflammation via diurnal cortisol in a national sample of adults.
Perceived stress is linked to heightened biomarkers of inflammation via diurnal cortisol in a national sample of adults.
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在全国成年人样本中，通过昼夜皮质醇，感知到的压力与炎症的生物标志物增加有关。
DOI：
10.1016/j.bbi.2021.01.015
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Zilioli S
中科院分区：
文献类型：
--
作者：
Knight EL;Jiang Y;Rodriguez-Stanley J;Almeida DM;Engeland CG;Zilioli S
暴露于压力和对压力的感知与全身炎症的改变有关，但压力与炎症联系的中间过程尚不完全清楚。在大样本成人(即美国研究中的中年人群；n=914；55.9%女性；年龄34-84岁)中，研究了自我报告的心理社会压力与炎症[即C反应蛋白(CRP)、白介素6(IL-6)、纤维蛋白原、E-选择素和细胞间黏附分子-1(ICAM-1)]相关的途径--皮质醇斜率。结构方程模型显示，在这些横断面分析中，感觉到的心理压力与昼夜皮质醇斜率平坦和昼夜皮质醇斜率平坦与炎症加重相关(间接通路指数，ω=0.003，95%CI[0.001，0.004]，ωstd=0.027；协变量，ω=0.001，[0.0002，0.002]，ωstd=0.011)。对于自我报告的创伤性生活事件也有类似的间接影响(ω=0.007，[0.004，0.012]，ωstd=0.030)；然而，纳入协变量(即，年龄、性别、种族、民族、体重指数和其他与身体健康相关的因素)解释了这一发现(ω=0.001，[−0.001，0.004]，ωstd=0.005)。这些结果支持心身健康的平衡负荷模型，在该模型中，皮质醇(与其他应激反应信号分子一起)是理解应激暴露、感知应激和免疫功能之间联系的必要组成部分。
Exposure to and perceptions of stress have been associated with altered systemic inflammation, but the intermediate processes by which stress links to inflammation are not fully understood. Diurnal cortisol slopes were examined as a pathway by which self-reported psychosocial stress is associated with inflammation [i.e., C-reactive protein (CRP), interleukin-6 (IL-6), fibrinogen, E-Selectin, and Intercellular Adhesion Molecule-1 (ICAM-1)] in a large sample of adults (i.e., the Midlife in the US study; n = 914; 55.9% female; aged 34–84 years). Structural equation modeling indicated that perceived psychological stress was associated with flattened diurnal cortisol slopes and flatter diurnal cortisol slopes were, in turn, associated with heightened inflammation in these cross-sectional analyses (index of indirect pathway, ω = 0.003, 95% CI [0.001, 0.004], ωSTD = 0.027; with covariates, ω = 0.001, [0.0002, 0.002], ωSTD = 0.011). A similar indirect effect was evident for self-reported traumatic life events (ω = 0.007, [0.004, 0.012], ωSTD = 0.030); however, inclusion of covariates (i.e., age, gender, race, ethnicity, body mass index, and other factors associated with physical health) accounted for this finding (ω = 0.001, [−0.001, 0.004], ωSTD = 0.005). These results support an allostatic load model of psychosomatic health, in which cortisol (along with other stress-responsive signaling molecules) is a necessary component for understanding links between stress exposure, perceived stress, and immune functioning.
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影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
DOI：
10.1016/j.bbi.2020.07.017
发表时间：
2020-10
期刊：
Brain, behavior, and immunity
影响因子：
--
作者：
Cuevas AG;Ong AD;Carvalho K;Ho T;Chan SWC;Allen JD;Chen R;Rodgers J;Biba U;Williams DR
通讯作者：
Williams DR
影响因子：
3.7
作者：
Adam EK;Heissel JA;Zeiders KH;Richeson JA;Ross EC;Ehrlich KB;Levy DJ;Kemeny M;Brodish AB;Malanchuk O;Peck SC;Fuller-Rowell TE;Eccles JS
通讯作者：
Eccles JS
影响因子：
4
作者：
Hostinar, Camelia E.;Lachman, Margie E.;Miller, Gregory E.
通讯作者：
Miller, Gregory E.
昼夜皮质醇斜率以及心理和身体健康结果：系统评价和荟萃分析。
影响因子：
3.7
作者：
Adam EK;Quinn ME;Tavernier R;McQuillan MT;Dahlke KA;Gilbert KE
通讯作者：
Gilbert KE